Clinical Significance of Detection of Lymphocyte Subsets in Patients with Pulmonary Infection after Kidney Transplantation

Abstract

Abstract: Objective To explore and analysis the clinical significance of detection of lymphocyte subsets in patients with pulmonary infection after kidney transplantation. Methods From January 2020 to May 2022, 50 cases of postoperative patients who completed kidney transplantation in the Transplantation Center of the Second Affiliated Hospital of Guangxi Medical University were selected as the research subjects, and the content of lymphocyte subsets was detected. All patients were given immunosuppressive therapy after operation, and the incidence of pulmonary infection was followed up and correlation analysis was performed. Results Among the 50 patients, 12 cases (infection group) developed infection 6 months after surgery, accounting for 24.0%; Four pathogens infected were found(Klebsiella pneumoniae in 4 cases, Pseudomonas aeruginosa in 4 cases, Acinetobacter baumannii in 2 cases, Escherichia coli in 1 case and Candida albus in 1 case). The relative contents and absolute content of CD3⁺ and CD4⁺ lymphocyte subsets in the infection group were significantly lower than those in the non-infection group(P<0.05), and the relative contents and absolute content of CD8⁺ lymphocyte subsets were significantly higher than those in the non-infection group(P<0.05). Pearson analysis showed that the relative contents of CD3⁺, CD4⁺, CD8⁺ lymphocyte subsets and absolute content were correlated with the occurrence of pulmonary infection(P<0.05). Binary logistic regression analysis showed that the relative content and absolute content of CD3⁺, CD4⁺, CD8⁺ lymphocyte subsets were the important factors that affected the occurrence of pulmonary infection(P<0.05). Conclusion Pulmonary infection is common after kidney transplantation. The relative content of CD3⁺, CD4⁺, and CD8⁺ lymphocyte subsets are correlated with the occurrence of pulmonary infection. The detection of lymphocyte subsets can effectively predict the occurrence of pulmonary infection in patients.

Key words: kidney transplantation, pulmonary infection, lymphocyte subsets, correlation, multivariate analysis, pseudomonas aeruginosa

CLC Number:

ZHOU Ming-zhen, SUN Xu-yong. Clinical Significance of Detection of Lymphocyte Subsets in Patients with Pulmonary Infection after Kidney Transplantation[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(10): 12-15.

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