Table of Content

16 September 2022, Volume 40 Issue 18

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Establishment of Two Kinds of Alcohol-dependent Free Drinking Modelsin Sprague–Dawley Rats

LI Qi, AN Zi-yi, DONG Ze-song, LIU Hong-feng, LI Shu, BI Peng-xiang, HUO Nan-nan, ZHU Xiao-feng

2022, 40(18):  1-4. 

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Objective To establish two kinds of free drinking models of SD rats with alcohol dependence, and to provide experimental basis for animal experiment of alcohol dependence. Methods SD-rats (n=30, male) were randomly divided into control group (n=10), 10% double-bottle model group(n=10) and 20% double-bottle model group (n=10), after 28 days of modeling, the behavioral tests (elevated plus maze, morris water maze) and the scores of ethanol withdrawal syndrome were performed. Results There was no significant difference in body weight among the three groups (P>0.05), alcohol intake in the two groups reached the plateau stage, water intake decreased with the increase of alcohol intake, and alcohol preference increased to the stability (P<0.05). In the elevated plus maze test, the times of open arm entry and the retention time of open arm in the model group were significantly lower than in the control group (P<0.05), and in the morris water maze test, the memory ability in the model group was lower than in the control group (P<0.05). The 24-hour abstinence score of the model group was higher than that of the control group (P<0.05). Conclusion Both of the two methods can be used to carry out the experimental study of alcohol dependence in animals.

Preliminary Practice of Ultrasound in Nephrology Specialist Training

XIAN Wei, DONG Yan-hu, DONG JI, YUE Ying, SI Jian-ping

2022, 40(18):  5-7. 

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Resident standardized training is an important part of medical education. After graduation, medical students face the organic combination of theory and clinical practice. As a bridge between theory and clinical practice, resident standardized training is particularly important. At present, medical imaging technology is an important part of the training for the students of routine training. The traditional routine training teaching mode is slightly insufficient in the imaging technology of each specialty. The nephrology specialty involves more and more imaging technology to guide the clinical practice. There is an urgent need for new teaching methods and technologies to be applied to the routine training teaching, and to strengthen the learning and practice of imaging technology, Combined with the current key technologies commonly used in nephrology specialty, we can solve the difficulties faced by resident standardized training in nephrology specialty. This paper discusses the importance of image technology in the standardized training of professional residents by strengthening the innovation of professional training teaching mode, cultivating the learning initiative of students, and promoting the construction of professional training teachers and disciplines.

Evaluation of Hyperbaric Oxygen Combined with Drugs in the Treatment of Early Brain Nerve Injury

FU Wei, LIU Fei, HUANG Rui, ZHANG Xu-dong, LIANG Jun, YAN Lei, ZHANG Ping

2022, 40(18):  8-11. 

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Objective To analyze the clinical effect of hyperbaric oxygen combined with pharmacotherapy in the early stage of cerebral nerve injury. Methods Fifty patients with brain nerve injury treated in the Hongqi Hospital Affiliated to Mudanjiang Medical College from February 2019 to January 2021 were selected as the research objects. They were randomly divided into the exploration group and the general group, with 25 cases in each group. The study group was treated with hyperbaric oxygen combined with nitroglycerin and aspirin enteric coated tablets, while the general group was treated with nitroglycerin and aspirin enteric coated tablets. The neurological deficit score, motor function score, swallowing function score, life ability score, neurological function improvement time, motor function improvement time, swallowing function improvement time and hospitalization time of the two groups were compared before and after treatment, and the treatment efficiency and the incidence of adverse reactions were calculated and compared. Results After treatment, compared to control group, the neural deficiency score of the investigation group was lower, whereas the movement function score, swallowing function score and living ability score were higher, which was significant in statistics(P<0.05). By comparison with control group, the improvement time of movement function, improvement time of swallowing function and hospital stay in investigation group were significantly much shorter, which was significant in statistics(P<0.05). The response rate of investigation group was higher than that of control group, while the incidence of side effects was lower, which was significant in statistics(P < 0.05). Conclusion The application of hyperbaric oxygen combined with pharmacotherapy in the treatment of cerebral nerve injury could shorten the time of symptoms, improve the deficiency of neural function, and enhance the movement function, swallowing function and living ability of patients.

Construction of Transitional Care Plan for Stroke Patients with Hemiplegia Based on Workshop Mode

MA Lian-qin, BIE Yong-qing, YANG Jiang-bo, CHEN Yan-ling, TAI Shi-bin, LI Hua, WANG, Bing-feng LI Qing-ling

2022, 40(18):  12-14. 

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Objective This study was to construct a continuous care plan for stroke patients with hemiplegia based on workshop mode, it can provide reference for the continuous care of stroke patients with hemiplegia. Methods in this study, in the standard under the guidance of the theory and group dynamics theory, comprehensive multi-disciplinary professional and technical personnel to the ideas and opinions, using literature research, form based on the pattern of workshop of stroke patients with hemiplegia care plan draft, enquiry for demonstration by experts, improve cerebral apoplexy hemiplegia patients based on the workshop mode continue care plan. Results The recovery rates of the two rounds of questionnaires were 100%, and the expert authority coefficients were 0.82 and 0.89. Finally, it was determined that the workshop members would give continuous care to stroke patients with hemiplegia and their primary family caregivers (PFC) once every 2 weeks. The corresponding PPT presentation was selected according to the patients' ability of daily living activities (BI) score, and personalized common goals were formulated. Meanwhile, the achievement of the last common goal was evaluated. BI and motor function (FMA) scores of stroke patients with hemiplegia were observed. Conclusion In this study, the construction of continuous care plan for stroke patients with hemiplegia based on workshop mode is scientific, and helpful to guide the practice of continuous care.

Efficacy of N-acetylcysteine Combined with HRZE Regimen in the Treatment of Patients with Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Tuberculosis

LI Xiao-ying, CHEN Xuan

2022, 40(18):  15-18. 

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Objective To investigate and analysis the efficacy of N-acetylcysteine combined with HRZE regimen in the treatment of patients with chronic obstructive pulmonary disease complicated with pulmonary tuberculosis. Methods Eighty-eight patients with chronic obstructive pulmonary disease and pulmonary tuberculosis who were diagnosed and treated in Guiyang Public Health Treatment Center from September 2018 to January 2022 were selected as the research subjects, and the patients were divided into N-acetylcysteine group and control group according to random number table. There were 44 cases in each group. The control group were treated with HRZE regimen, and the N-acetylcysteine group were treated with N-acetylcysteine based on the treatment of the control group. Both groups were treated for 3 months. The total effective rate, pulmonary function indicators [forced vital capacity (FVC), 1-second forced expiratory volume (FEV₁)], serum interleukin-6 (IL-6), and incidence of adverse reactions were compared between the two groups. Results The total effective rate in two groups during treatment was not significantly difference(P>0.05). There was no significant difference in FVC and FEV₁ between the two groups before treatment (P>0.05), were higher than those before treatment (P<0.05), and the N-acetylcysteine group was significantly higher than the control group (P<0.05). There was no significant difference in serum IL-6 content between the two groups before treatment (P>0.05). The serum IL-6 content in the two groups after treatment was significantly lower than before treatment (P<0.05). Acetylcysteine group was also significantly lower than the control group (P<0.05). The incidence of adverse reactions in two groups during treatment was not significantly difference(P>0.05). Conclusion N-acetylcysteine combined with HRZE regimen in the treatment of chronic obstructive pulmonary disease complicated with pulmonary tuberculosis can can effectively inhibit the expression of serum inflammatory factors, improve the patient's pulmonary function, and improve the therapeutic effect, increase the occurrence of adverse reactions.

Relationship between Preoperative Hemoglobin Level and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgery

ZHAO Wan-li, NI Xin-li

2022, 40(18):  19-21. 

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Objective To explore and analysis the relationship between preoperative hemoglobin level and postoperative delirium in elderly patients undergoing abdominal surgery. Methods From August 2021 to March 2022, 216 elderly patients who underwent abdominal surgery in the General Hospital of Ningxia Medical University were retrospective selection as the research subjects. According to whether delirium occurred, they were divided into delirium group(n=32) and non-delirium group(n=184). Investigate and record the general information of all patients, including gender, age, anesthesia ASA classification, anesthesia time, operation time, intraoperative blood loss, fasting blood glucose, albumin, etc. The hemoglobin levels were monitored in all patients 1 day before surgery and the day after surgery. Postoperative delirium was assessed by the Confusion Assessment Method(CAM), and Pearson analysis was used for correlation analysis. Multivariate Logistic stepwise regression analysis was used for influencing factor analysis, and ROC curve analysis was used for predictive value analysis. Results There was no significant difference in sex, age, ASA grade, anesthesia time, operation time, intraoperative bleeding and albumin compared between delirium group and non delirium group (P>0.05). The hemoglobin level of delirium group was significantly lower than that of non delirium group (P<0.05). In the 216 patients, Pearson analysis showed that there was correlation between hemoglobin level on the 1st day before operation and delirium on the 5th day after operation (P<0.05). Multivariate logistic stepwise regression analysis showed that the level of hemoglobin 1 day before operation was an important factor leading to delirium 5 days after operation (P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve of hemoglobin level 1 day before operation to predict delirium 5 days after operation was 0.670. Conclusion Elderly patients with abdominal surgery are prone to postoperative delirium. There is positive correlation between preoperative hemoglobin level and postoperative delirium. It is also an important factor leading to delirium and can also predict the occurrence of postoperative delirium.

Effects of Different Doses of Propofol on Fatigue Syndrome in Elderly Patients Undergoing Painless Gastroscopy

WANG Zhan

2022, 40(18):  22-25. 

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Objective To investigate the effect of different propofol dosages on postoperative fatigue syndrome (POFS) in elderly patients under painless gastroscopy. Methods From September 2017 to September 2021, 70 cases of elderly patients who underwent painless gastroscopy in Jiangsu Province Nantong City Hospital of Traditional Chinese Medicine were selected as the research objects. The patients were divided into high-dose group and low-dose group with 35 patients in each groups accorded to the principle of random envelope drawing. All patients were given intravenous anesthesia with propofol combined with dezocine, and the high-dose group was given intravenous propofol 2.0 mg/kg anesthesia, and low-dose group were given intravenous propofol 1.0mg/kg anesthesia. The postoperative fatigue syndrome and adverse reactions were recorded, and anesthesia effect and hemodynamic changes were observed. Results There were no significant difference in the time of disappearance of consciousness compared between the two groups (P>0.05). The low-dose group's awake time, wake-up time, and propofol dosage were less than the high-dose group ,and the difference was statistically significant(P<0.05). There were no significant difference in pulse oxygen saturation(SpO₂), Heart rate(HR) and Mean arterial pressure(MAP) compared between the two groups before and 10 min after anesthesia (P>0.05), and were all within the normal range. The incidence of adverse reactions such as respiratory depression, coughing, motor reactions, nausea and vomiting at 24 hours after anesthesia in the low-dose group were lower than high-dose group, and the difference was statistically significant(P<0.05). The incidence and duration of postoperative fatigue syndrome in the low-dose group were less than those in the high-dose group, and the difference was statistically significant(P<0.05). Conclusion In elderly patients undergoing painless gastroscopy, the application of low-dose propofol can effectively shorten the occurrence time of postoperative fatigue syndrome, and reduce the incidence of postoperative fatigue syndrome, without affecting the patient's hemodynamic status, and can promote patient recovery and reduce the occurrence of adverse reactions.