Effects of Different Doses of Propofol on Fatigue Syndrome in Elderly Patients Undergoing Painless Gastroscopy

Abstract

Abstract: Objective To investigate the effect of different propofol dosages on postoperative fatigue syndrome (POFS) in elderly patients under painless gastroscopy. Methods From September 2017 to September 2021, 70 cases of elderly patients who underwent painless gastroscopy in Jiangsu Province Nantong City Hospital of Traditional Chinese Medicine were selected as the research objects. The patients were divided into high-dose group and low-dose group with 35 patients in each groups accorded to the principle of random envelope drawing. All patients were given intravenous anesthesia with propofol combined with dezocine, and the high-dose group was given intravenous propofol 2.0 mg/kg anesthesia, and low-dose group were given intravenous propofol 1.0mg/kg anesthesia. The postoperative fatigue syndrome and adverse reactions were recorded, and anesthesia effect and hemodynamic changes were observed. Results There were no significant difference in the time of disappearance of consciousness compared between the two groups (P>0.05). The low-dose group's awake time, wake-up time, and propofol dosage were less than the high-dose group ,and the difference was statistically significant(P<0.05). There were no significant difference in pulse oxygen saturation(SpO₂), Heart rate(HR) and Mean arterial pressure(MAP) compared between the two groups before and 10 min after anesthesia (P>0.05), and were all within the normal range. The incidence of adverse reactions such as respiratory depression, coughing, motor reactions, nausea and vomiting at 24 hours after anesthesia in the low-dose group were lower than high-dose group, and the difference was statistically significant(P<0.05). The incidence and duration of postoperative fatigue syndrome in the low-dose group were less than those in the high-dose group, and the difference was statistically significant(P<0.05). Conclusion In elderly patients undergoing painless gastroscopy, the application of low-dose propofol can effectively shorten the occurrence time of postoperative fatigue syndrome, and reduce the incidence of postoperative fatigue syndrome, without affecting the patient's hemodynamic status, and can promote patient recovery and reduce the occurrence of adverse reactions.

Key words: dose, propofol, painless gastroscopy, postoperative fatigue syndrome, wake time

CLC Number:

R614.2

WANG Zhan. Effects of Different Doses of Propofol on Fatigue Syndrome in Elderly Patients Undergoing Painless Gastroscopy[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(18): 22-25.

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