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Table of Content

    16 March 2025, Volume 43 Issue 6
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    Observation of Clinical Effect of Eliminating Phlegm and Supplementing Deficiency on Phlegm-Turbidity-Obstructing Lung Type AECOPD
    SHAO Rui-lin, SHUI Jing-wei, WANG Jin-zhong
    2025, 43(6):  1-6. 
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    Objective To observe the clinical effect of eliminating phlegm and supplementing deficiency on acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Collect the diagnosis and treatment data of AECOPD patients with phlegm obstructing lung type in the Department of Pulmonary Disease, Conghua District Traditional Chinese Medicine Hospital, Guangzhou from January 1, 2015 to December 31, 2023, and screen the data according to the inclusion and exclusion criteria. The included data were divided into an observation group and a control group based on whether the basic formula for resolving phlegm and tonifying deficiency was used for treatment. Two groups were matched using propensity score matching (PSM) to achieve baseline balance and comparability. The inflammation immune indicators, ventilation function (blood gas analysis), glucocorticoid use (inhaled and intravenous glucocorticoids), and quantitative scores of traditional Chinese medicine clinical symptoms (cough, expectoration, sputum quality, sputum color, wheezing, fever) were compared between the two groups before and after treatment to evaluate the clinical efficacy of the method of resolving phlegm and supplementing deficiency in AECOPD patients. Results A total of 401 patient data were included, including 256 in the observation group and 145 in the control group. Using SPSS 26.0 for propensity score matching, 135 cases were successfully matched to the observation group and 135 cases to the control group. Due to the inconsistent timing of efficacy evaluation among different cases, after successful matching, the generalized estimation equation (GEE) was used to compare the changes in TCM syndrome scores and test indicators between the two groups of cases before and after treatment. It was found that the trend of TCM syndrome score decline in the observation group was more significant and statistically significant difference than that in the control group(P<0.05). The rising and falling trends of the inspection indicators are not consistent, but the changing trends of these inspection indicators were not statistically significant difference(P>0.05). Conclusion In this study, the method of resolving phlegm and supplementing deficiency had a significant symptom relief effect on AECOPD patients with phlegm turbidity obstructing lung type, but did not significantly improve inflammatory and blood gas analysis indicators, which may be related to sample size.
    Network Pharmacology Study of Houttuyniae Herba in Treatment of Insulin Resistance:Potential Targets and Mechanisms
    WANG Jin-xing-yi, GAO Jie-jie, LIU Yang, XIA Jie, HE Lu, SHI Jun-wei, DI Ya-nan
    2025, 43(6):  6-11. 
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    Objective To explore the potential mechanism of Houttuynia herba on improving insulin resistance (IR) using network pharmacology. Methods The chemical compounds and potential targets of Houttuynia Herba were obtained by TCMSP database. Targets related to IR d were obtained by Genecards database. Meanwhile, the intersection targets of the Houttuynia herba were obtained by venny2.1.0 online. The “herbs-active components targets” and protein interaction (PPI) network of potential target were constructed by cystoscape 3.9.0 software and STRING database. The GO analysis and KEGG enrichment analysis were performed by Matascape database. Results There were 7 active components and 84 potential targets of Houttuynia Herba for IR ameliorating. Active components with high scores were quercetin and kaempferol. The key targets were transcription factor AP-1 (JUN), cell tumor antigen p53 (TP53), mitogen activated protein kinase-1 (MAPK1), etc. The related metabolic process was related to hormone response, lipid binding and so on. The KEGG pathways were enriched in pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis, etc. Conclusion Houttuynia Herba may play a role in the treatment of IR mainly through quercetin and kaempferol to regulate the late glycation products and their receptor signals, lipids, atherosclerosis and other related signal pathways in the complications of cancer and diabetes.
    Reliability and Validity of the Chinese Version of the Pelvic Girdle Questionnaire in Patients with Pelvic Girdle Pain and Urinary Incontinence
    CHEN Qian-qian, LIN Zi-ling, ZHENG Xiu-ping, LUO Jia, WU Juan, WANG Xiang-bin
    2025, 43(6):  11-15. 
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    Objective To test the reliability and validity of the Chinese version of the Pelvic Girdle Questionnaire in patients with pelvic girdle pain and urinary incontinence, and to provide a basis for its clinical and scientific use. Methods A total of 131 female patients with pelvic girth pain and urinary incontinence who were admitted to the Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine from April 2022 to June 2023 were selected and filled out the relevant questionnaires, and internal consistency reliability, test-retest reliability, floor and ceiling effect, construct validity and discriminative validity of the Chinese pelvic girdle questionnaire were analyzed. Results A total of 96 valid questionnaires were collected. The Cronbach coefficient of the questionnaire was 0.962, the test-retest reliability was 0.851. The Chinese version of the pelvic girdle questionnaire did not have floor or ceiling effect. The PGQ total score, PGQactivity score, and PGQsymptom score are highly correlated with ODI and NRS scores. Conclusion The Chinese version of PGQ has good reliability and validity, and can be used to evaluate the function of patients with pelvic girdle pain and urinary incontinence as a clinical outcome indicator.
    Analysis of the Relationship between Hp Infection, CyclinD1, CA72-4, P53 and Tumor Stage in Patients with Gastric Cancer
    LI Jiang-feng, ZHU De-xing, XU Yi-han
    2025, 43(6):  15-18. 
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    Objective To investigate the relationship between Helicobacter pylori (Hp) infection and cell cycle protein D1 (CyclinD1), carbohydrate protein 72-4 (CA72-4), P53 and tumor stage in patients with gastric cancer. Methods 120 patients with gastric cancer diagnosed and treated in our hospital from June 2021 to June 2024 were divided into HP-positive group (n=30) and HP-negative group (n=30) according to their Hp infection status. Hp infection was detected by modified Giemsa staining and 13C breath test. The positive expression rates of CyclinD1 and P53 were evaluated by immunohistochemistry, and the levels of CA72-4 were detected by electrochemiluminescence immunoassay. Spearman correlation analysis was used to investigate the relationship between Hp infection and CyclinD1, CA72-4 and P53. Results The positive rates of CyclinD1, P53 and CA72-4 in HP-positive group were higher than HP-negative group, and the differences were statistically significant (P<0.05). There was no difference in tumor stage between the two groups (P>0.05). Spearman correlation analysis showed that baseline superbaseline (DOB) of Hp infection was positively correlated with CyclinD1 (r=0.781, P=0.004) and CA72-4 (r=0.553, P=0.002), but negatively correlated with P53 (r=-0.362, P=0.041). Conclusion Hp infection is closely related to the expression levels of CyclinD1, CA72-4 and P53 in gastric cancer patients, but not related to tumor stage.
    Clinical Efficacy Observation of Heat Sensitive Moxibustion combined with Buzhong Yiqi Decoction for the Treatment of Allergic Rhinitis Lung Spleen with Qi Defi ciency Syndrome
    XU Hai-yan, ZHANG Lin, XU Min, ZHU Dao-cheng, XU Wei
    2025, 43(6):  19-23. 
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    Objective Compared with conventional Western medicine, the clinical efficacy of treating allergic rhinitis patients with lung-spleen qi deficiency syndrome using heat-sensitive moxibustion combined with Bu Zhong Yi Qi Tang was observed. Methods Randomized controlled trial design was adopted. Sixty eligible subjects were included. They were divided into two groups by random number table method. Experimental group (n=30) : heat-sensitive moxibustion combined with Buzhong Yiqi decoction; Control group (n=30) : the conventional antiallergic drug loratadine. Both groups were treated once a day, 5 times/week, 10 times as a course of treatment. Total Nasal Symptom Score (TNSS) , Total Non-Nasal Symptom Score (TNNSS), nasal conjunctivitis Quality of Life scale (RQLQ) and clinical efficacy were evaluated after a total of 2 courses of treatment. Results Before intervention, there was no significant difference in age, gender, TNSS score, RQLQ score and TNNSS score between the two groups (P>0.05). After the intervention, the experimental group showed superior improvements in TNSS, TNNSS, and RQLQ scores compared with the control group, with statistically significant differences (P<0.05).The total effective rate of the experimental group was 90.00%, higher than that of the control group 76.67%, the difference was statistically significant (P<0.05). Conclusion Heat sensitive moxibustion combined with Buzhong Yiqi Decoction in the treatment of allergic rhinitis lung qi deficiency syndrome of clinical advantage.
    Research Progress of Chinese Medicine Treatment in Postoperative Gastrointestinal Dysfunction of Gynecologic Oncology
    LIU Meng-qi, HAN Ya-mei, LI Meng-ge, WANG Wen-cui, YIN Jun-xia, WANG Ya
    2025, 43(6):  84-86. 
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    In recent years, the incidence of gynecologic tumors has continued to rise in China. Surgery is one of the main methods to treat gynecologic tumors, but postoperative patients often face a series of complications, especially the occurrence of gastrointestinal dysfunction (PGID) is the most common. Traditional Chinese medicine (TCM) therapy has received widespread attention in promoting the recovery of postoperative gastrointestinal function through internal administration of traditional Chinese medicine (TCM), warm acupuncture and moxibustion, thunder fire moxibustion, auricular acupuncture point burying beans, TCM acupoint plastering, and TCM hot omega packs. In this study, we investigated the application of TCM therapy in gastrointestinal function of postoperative gynecologic oncology patients.
    Influence of Blood Health Education on Students' Knowledge, Attitude and Practice of Voluntary Blood Donation
    DING Shu-rong, SUN Hui-juan
    2025, 43(6):  101-103. 
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    Objective To study the influence of blood health education on knowledge, attitude and practice of voluntary blood donation among students. Methods 40 third year students in a middle school and 80 first year students in a university in Yantai were selected and randomly divided into the control group and the research group, with 60 students in each group, including 20 middle school students and 40 college students. There was no significant difference in gender and age between the research group and the control group (P>0.05). The control group did not carry out blood health education, while the research group carried out diversified blood health education, including visiting the Science Museum of voluntary blood donation, blood health knowledge lectures, blood station open day, new media micro class . Three months later, the two groups of students used the same questionnaire to investigate and evaluate the effect. Results The awareness rate of related knowledge of voluntary blood donation, blood donation motivation, blood donation willingness, blood donation number, the total blood donation volume and blood donation 400 mL number of students in the research group were higher than those in the control group, and students' concerns were lower than those in the control group, the differences were statistically significant (p<0.05). Conclusion The implementation of blood health education for students can help students improve their knowledge, attitude and practice of voluntary blood donation and alleviate the problem of blood source tension.
    Analysis of the Prevalence and Risk Factors of Chronic Kidney Disease among Community Physical Examination Population in a Certain Area of Anhui Province
    YIN Yue, YANG Guang, YANG Yuan-kuan, DING Sheng, LIU Tian-lu, YE Xing-li, WANG Wei-wen
    2025, 43(6):  104-108. 
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    Objective To explore the prevalence and risk factors of CKD among villagers in Shengli Village, Guangde City, Anhui Province. Methods A retrospective analysis was conducted on 492 completed health checkups from 2019 to 2022. CKD was screened through questionnaires, physical examinations, and laboratory examination results , and risk factors related to chronic kidney disease were analyzed. The results showed that among the 492 patients, the positive rate of urinary protein, decreased glomerular filtration rate, and the incidence rate of CKD were 22.2%, 7.7%, and 26.8% respectively. The results of logistic regression analysis showed that age(β=0.028,OR=1.03,95%CI: 1.00~1.05), hyperuricemia(β=0.55,OR=0.58,95%CI: 0.35~0.95), and kidney stone(β=0.48,OR=0.62,95%CI: 1.04~2.50) are independent risk factors for CKD. Conclusion The prevalence of CKD in the population undergoing physical examination in this village is relatively high. It is recommended to add urine albumin, urine creatinine, and urine sediment examination to improve the early detection rate of CKD.
    Application of ESPCS Education Model and Progressive Functional Rehabilitation Nursing in Elderly Patients with Osteoporotic Thoracolumbar Fractures
    ZHANG Cong-cong, LAN Yuan-mei, FENG Yue-ying, CHEN Tian-chao
    2025, 43(6):  112-115. 
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    Objective To explore the effect of using the ESPCS education model and progressive functional rehabilitation nursing in elderly patients with OTLF. Methods A total of 82 elderly OTLF patients from October 2022 to October 2023 who were admitted in Beijing Peking Union Medical College Hospital were selected, and divided into the intervention group (n=41, ESPCS education and progressive functional rehabilitation care) and the control group (n=41, routine nursing care) by different intervention methods . The knowledge and cognitive level of osteoporosis, pain level, lumbar spine function, daily living ability, and health behavior in both groups were compared. Results After intervention, the cognitive scores of osteoporosis knowledge in both groups were increased, and in comparision of the control group, the intervention group was higher (P<0.05). After intervention, VAS and ODI scores in both groups were decreased, and in comparision of the control group, the intervention group was lower (P<0.05). After intervention, the ADL scores in both groups were increased, and in comparision of the control group, the intervention group was higher (P<0.05). After intervention, the health behavior scores in both groups were increased, and in comparision of the control group, the intervention group was higher (P<0.05). Conclusion The application of ESPCS education model and progressive functional rehabilitation nursing in elderly OTLF patients can improve lumbar spine function, healthy behavior, enhance knowledge and cognitive level of osteoporosis, daily living ability, and alleviate pain level.
    The Effect of Bbundle Pain Management on Self-Care Ability and Complications of Patients after External and Internal Ligation of Circular Mixed Hemorrhoids
    KONG Gui-xiang
    2025, 43(6):  115-119. 
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    Objective To explore the effect of bundle pain management on self-care ability and complications in patients with circular mixed hemorrhoids after external and internal ligation. Methods Eighty patients with circular mixed hemorrhoids who underwent external and internal ligation in Heze hospital of traditional chinese medicine from February 2022 to February 2024 were randomly divided into two groups, each with 40 cases. The control group received routine management, while the observation group received bundle pain management. The pain [Visual Analog Scale (VAS)], self-care ability [Self care Ability Scale (ESCA)], complications, and quality of life [Chinese version of Health Survey Brief (SF-36)] were compared between the two groups using a digital table method. Results Comparison of the VAS scores of the 2 groups before management, the difference was not statistically significant (P>0.05), after management, the VAS scores of the observation group were lower than those of the control group, and the difference was statistically significant (P<0.05). Comparison of the ESCA scores of the 2 groups before management, the difference was not statistically significant (P>0.05), and after management, the scores of the ESCA dimensions of the observation group were higher than those of the control group, and the difference was statistically significant (P<0.05). The complication rate of the observation group was lower than that of the control group, and the difference was statistically significant (P<0.05). Comparison of SF-36 scores between the 2 groups before management, the difference was not statistically significant iso (P>0.05), after management, the SF-36 scores of each dimension in the observation group were higher than those in the control group, and the difference was statistically significant (P<0.05). Conclusion Bundled pain management can help alleviate postoperative pain in patients with circular mixed hemorrhoids, improve their self-care ability, reduce the occurrence of complications, and improve their quality of life.
    Application of Cancer Nursing Plan and Empathy Nursing Under the Guidance of Risk Concept in Breast Cancer Patients Undergoing Radiotherapy
    CUI Meng-fei, ZHAO Jing
    2025, 43(6):  135-138. 
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    Objective To explore the effect of cancer nursing plan and empathy nursing under the guidance of risk concept for breast cancer patients undergoing radiotherapy. Methods A total of 420 patients with breast cancer from July 2021 to July 2022 who were received radiotherapy in Binzhou Central Hospital were selected as the control group, was given routine nursing intervention, and a total of 420 patients with breast cancer from August 2022 to August 2023 who were selected as the study group, was given tumor nursing plan and empathy nursing intervention under the guidance of risk concept. Cancer related fatigue, shame and quality of life were compared in both groups. Results After intervention, the Cancer Fatigue Scale (CFS) scores in both groups were decreased, and in comparision of the control group, the intervention group was lower, with a statistically significant difference (P<0.05). After intervention, the Social Impact Scale (SIS) scores in both groups were decreased, and in comparision of the control group, the intervention group was lower, with a statistically significant difference (P<0.05). After intervention, Functional Assessment of Cancer Therapy Break (FACT-B) scores in both groups were increased, the score of the intervention group was higher than that of the control group, with a statistically significant difference (P<0.05). Conclusion The application of cancer care plan and empathy nursing under the guidance of risk concept in the intervention of breast cancer patients with radiotherapy can alleviate cancer-related fatigue, alleviate the sense of shame, and improve the quality of life.
    Application of Root Analysis of PICC Catheter Risk Management in Neonatus
    PAN Chang-yan, ZHAO Kai-li
    2025, 43(6):  139-142. 
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    Effect of Wuling Capsule and Sinos on Efficacy and Symptom Improvement in Patients with Anxiety and Sleep Disorders
    SHANG Wei-fang
    2025, 43(6):  176-180. 
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    Objective To take the combination treatment of Wuling capsule and SinOS (zolpidem tartrate tablets) for patients with anxiety and sleep disorders,and explore and analyze the clinical treatment effects of the combination and its effects on symptom improvement. Methods A total of 82 patients with anxiety and sleep disorders admitted to our hospital from May 2023 to May 2024 were selected and divided into control group and observation group based on the random number table method, and the case number of each group was consistent. Among them, the control group only applied Snow treatment, while the observation group took the combination of Wuling capsule and Snow treatment to study and analyze the clinical treatment effect of different medication schemes and the improvement of symptoms. Results The treatment Pittsburgh sleep quality score (PSQI), anxiety score (SAS), symptom score, and incidence of adverse effects were lower than the control group, with higher levels of serotonin(5-HT), brain-derived neurotrophic factor(BDNF), and γ-aminobutyric acid (GABA), statistically significant(P<0.05). Conclusion Combined treatment of Wuling capsule and SinOS for patients with anxiety and sleep disorders can improve disease symptoms, improve sleep quality and reduce the incidence of adverse reactions.
    Study of the Effect of Dapagliflozin Combined with Metformin in the Treatment of Obesity/Overweight Type 2 Diabetes Mellitus
    ZHOU Wen-ming, JI Li
    2025, 43(6):  184-187. 
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    Objective To explore the efficacy of daggligin combined with metformin in obese/overweight type 2 diabetes patients. Methods The clinical data of 70 obese/overweight type 2 diabetes patients hospitalized in Taizhou Hospital of Traditional Chinese and Western Medicine from December 2022 to December 2023 were retrospectively analyzed. According to different treatment methods , the patients were divided into two groups of 35 cases, and the observation group of 35 cases. The control group was treated with metformin, while the observation group was treated with dapagliflozin tablets and their blood glucose, body mass index (BMI), homocysteine (Hcy) levels, and blood lipid indicators (total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol) were measured. Results The observation group showed better blood glucose control than the control group (P<0.05). The BMI of the observation group patients after treatment was (23.02±0.12) kg/m2, while that of the control group was (25.23±0.31) kg/m2. The observation group had a lower BMI and the difference was statistically significant (t=8.451, P<0.001). The Hcy index of the observation group after treatment was (7.00±1.04) μmol/L, while that of the control group was (10.85±2.14) μmol/L. The observation group had a lower BMI and the difference was statistically significant (t=6.254, P<0.001). Conclusion Daggligin combined with metformin is an effective and stable method for the combined treatment of obesity/overweight type 2 diabetes.