Network Pharmacology Study of Houttuyniae Herba in Treatment of Insulin Resistance:Potential Targets and Mechanisms

Abstract

Abstract: Objective To explore the potential mechanism of Houttuynia herba on improving insulin resistance (IR) using network pharmacology. Methods The chemical compounds and potential targets of Houttuynia Herba were obtained by TCMSP database. Targets related to IR d were obtained by Genecards database. Meanwhile, the intersection targets of the Houttuynia herba were obtained by venny2.1.0 online. The “herbs-active components targets” and protein interaction (PPI) network of potential target were constructed by cystoscape 3.9.0 software and STRING database. The GO analysis and KEGG enrichment analysis were performed by Matascape database. Results There were 7 active components and 84 potential targets of Houttuynia Herba for IR ameliorating. Active components with high scores were quercetin and kaempferol. The key targets were transcription factor AP-1 (JUN), cell tumor antigen p53 (TP53), mitogen activated protein kinase-1 (MAPK1), etc. The related metabolic process was related to hormone response, lipid binding and so on. The KEGG pathways were enriched in pathways in cancer, AGE-RAGE signaling pathway in diabetic complications, lipid and atherosclerosis, etc. Conclusion Houttuynia Herba may play a role in the treatment of IR mainly through quercetin and kaempferol to regulate the late glycation products and their receptor signals, lipids, atherosclerosis and other related signal pathways in the complications of cancer and diabetes.

Key words: Houttuynia Herba, insulin resistance, network pharmacology, signaling pathway

CLC Number:

R285

WANG Jin-xing-yi, GAO Jie-jie, LIU Yang, XIA Jie, HE Lu, SHI Jun-wei, DI Ya-nan. Network Pharmacology Study of Houttuyniae Herba in Treatment of Insulin Resistance:Potential Targets and Mechanisms[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(6): 6-11.

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