Effect of Plasma Homocysteine on Blood Pressure and Cardiovascular Events in Patients with Acute ST-segment Elevation Myocardial Infarction

Abstract

Abstract: Objective To investigate the effect of plasma homocysteine (Hcy) on Central arterial pressure (CAP) and major adverse cardiovascular events (MACE) in patients with acute ST-segment elevation myocardial infarction (STEMI). Methods A total of 122 patients with STEMI who received emergency percutaneous coronary intervention (PCI) were divided into normal Hcy group (Hcy<15 μmol/L, n=80) and high Hcy group (Hcy≥15 μmol/L, n=42) according to plasma Hcy level, and the clinical data of the two groups were compared. The Kaplan-Meier method was used to plot the survival curve of patients and compare the effects of different factors on MACE in STEMI patients. Cox regression analysis was used to explore the risk factors for MACE in STEMI patients. Results The proportion of hypertension, central arterial systolic blood pressure (CASP) and brachial artery systolic blood pressure (SBP) were higher in the high Hcy group than in the normal Hcy group (P<0.05). Pearson correlation analysis showed that plasma Hcy was positively correlated with CASP, SBP and brachial artery diastolic blood pressure (DBP) (P<0.05). Kaplan-Meier survival curve analysis showed that patients with CAPP≥51.5 mm Hg, PP≥52 mm Hg, smoking and degree of lesions had an increased risk of MACE (P<0.05). Multivariate Cox regression analysis showed that smoking and PP were independent risk factors for MACE in patients with STEMI (P<0.05). Conclusion Plasma Hcy is closely related to blood pressure levels, smoking and PP are independent risk factors for MACE in STEMI patients.

Key words: homocysteine, acute myocardial infarction, percutaneous coronary intervention, cardiovascular events

CLC Number:

R543.3

XIN Lin-ze, ZHANG Yi-ming, GAO Zong-peng, HUANG Jian-ying, XU Yao. Effect of Plasma Homocysteine on Blood Pressure and Cardiovascular Events in Patients with Acute ST-segment Elevation Myocardial Infarction[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(15): 179-183.

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