Abstract: Objective The study was to investigate the correlation between the clinical syndromes of traditional Chinese medicine and coagulation indexes and the degree of coronary artery stenosis in patients with unstable angina pectoris (UA). Methods 120 patients admited to Wuxi Second Traditional Chinese Medicine Hospital from February 2018 to February 2020 were included in the study. Fibrinogen (FIB) level, prothrombin time (PT), thrombin time (TT), CT-1, hs-CRP and Lp-PLA2 values were determined, and eGRF values were calculated to analyze the correlation between TCM syndrome types and their correlation. Results The difference of FIB in each syndrome type was statistically significant (P<0.05). FIB level of patients with Blood stasis syndrome was significantly higher than that of the other three syndromes, and FIB level of patients with phlegm-stasis syndrome was significantly lower than that of the other three syndromes. There was no statistically significant difference in PT and TT among all syndromes（P>0.05）. There were significant statistical differences between CT-1, hs-CRP, Lp-PLA2 and eGRF of each syndrome type and the control group（P<0.05）.The CT-1 and hs CRP values of patients with Qi deficiency and blood stasis syndrome and phlegm stasis syndrome are significantly higher than those of patients with heart blood stasis obstruction syndrome and Qi yin deficiency syndrome. The Lp-PLA2 and eGRF values of patients with phlegm stasis syndrome and heart blood stasis syndrome are significantly higher than those of patients with qi deficiency and blood stasis syndrome. There were statistically significant differences in CT-1, hs CRP, Lp PLA2, and eGRF between patients with different degrees of coronary artery stenosis and the control group (P<0.05). Conclusion In 120 patients, the syndrome of qi deficiency and blood stasis > Mutual accumulation of phlegm and blood stasis > Deficiency of qi and Yin. The fibrinogen (FIB) value of the syndrome was significantly higher than that of other syndrome types. The levels of CT-1, hs-CRP, Lp-PLA2 and eGRF are closely related to the TCM syndrome type of unstable angina pectoris in patients. The expression level can help to understand the degree of coronary artery disease, provide the corresponding basis for clinical treatment, and play a role in the early prevention and treatment of coronary heart disease.

Key words: coronary heart disease, TCM syndrome type, coagulation function, correlation analysis