Abstract: Objective To explore and analysis the correlation between non-puerperal mastitis and prolactin, CD3⁺ and CD4⁺. Methods From December 2020 to August 2022, 80 non-lactation mastitis patients diagnosed and treated in Urumqi You'ai Hospital were selected as the observation group, 80 women who underwent physical examination were the control group. Serum prolactin content, serum immunoglobulin IgG, IgA, IgM content, CD3⁺T, CD4⁺T lymphocyte relative content in observation group and control group were detected and correlation analysis was carried out. Results The serum prolactin level of the observation group was significantly higher than that of the control group, the difference is statistically significant (P<0.05), and there was no significant difference in serum immunoglobulin IgG, IgA, and IgM compared between the two groups (P>0.05). The relative content of CD3⁺T and CD4⁺T lymphocytes in the peripheral blood of the observation group was significantly lower than that of the control group, the difference is statistically significant (P<0.05). Spearsman analysis showed that the serum prolactin level, the relative content of CD3⁺T and CD4⁺T lymphocytes in peripheral blood were correlated with the occurrence of non-lactation mastitis (P<0.05). Multivariate Logistic regression analysis showed that the serum prolactin level and the relative contents of CD3⁺T and CD4⁺T lymphocytes in peripheral blood were important factors leaded to the occurrence of non-lactation mastitis (P<0.05). Conclusion Patients with non-lactation mastitis are mostly accompanied by high expression of serum prolactin and lower relative contents of CD3⁺T and CD4⁺T lymphocytes. The occurrence of non-lactation mastitis are related to prolactin, CD3⁺T ,CD4⁺ T lymphocytes.

Key words: non-lactation mastitis, prolactin, CD3⁺T lymphocytes, CD4⁺T lymphocytes, correlation, multivariate analysis