Research Progress of Drugs for Acute Migraine Targeting CGRP and 5-HT1F Receptors

Abstract

Abstract: Present,the acute treatment of migraine includes non-specific pain relief and triptan drugs.The limitations of these drugs include: lack of efficacy in many patients, many side effects, contraindications of triptan drugs in patients with cardiovascular disease, and so on, which indicate that the demand for new treatments for migraine has not been met. The pharmacological study of 5-hydroxytryptamine (5-HT) has promoted the development of triptan drugs (5-HT_1B/1Dreceptor agonists), some of which act on 5-HT_1F receptors. The exploration of the role of calcitonin gene-related peptide (CGRP) has led to the development of CGRP receptor antagonists. This article reviews the main progress in the acute treatment of migraine with CGRP and 5-HT_1F receptors in recent years.

Key words: migraine, CGRP, 5-HT_1F, acute phase treatment, research progress

CLC Number:

R747.2

CHEN Ya-ru, ZAI Feng-lei. Research Progress of Drugs for Acute Migraine Targeting CGRP and 5-HT_1FReceptors[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(21): 64-67.

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Research Progress of Drugs for Acute Migraine Targeting CGRP and 5-HT_1FReceptors

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