Abstract: Objective To explore the influencing factors of rumination status in patients with postoperative chemotherapy for colorectal cancer, and to provide some reference for formulating corresponding countermeasures. Methods A total of 117 patients with colorectal cancer who received postoperative chemotherapy in the Sixth Affiliated Hospital of Sun Yat-sen University from January 2024 to March 2024 were selected as the subjects of this cross-sectional survey. The general data, rumination level, mental resilience level and perceptive social support level of patients with colorectal cancer were investigated by questionnaire, and the factors affecting rumination level of patients with colorectal cancer were analyzed. Results The score of invasive rumination was (12.92±5.06), and the score rate was 43.07%. Purposive rumination score (14.50±3.62), scoring rate of 48.33%; The correlation study indicated that the score of intrusive rumination was negatively correlated with the score of mental resilience and perceived social support, while purposive rumination had a positive correlation with the above two indicators(P<0.05). Multiple linear regression analysis revealed that gender, educational level, psychological resilience score, and perceptive social support score combined to affect the variability of intrusive rumination and purposive rumination, explaining 79% and 40.1% of the difference, respectively (P<0.05). Conclusion Patients with colorectal cancer generally lack active deep thinking, and the main influencing factors are gender, education level, mental resilience level and social support recognition level. In view of this, medical personnel should pay special attention to the psychological bearing problems of female patients and those with lower education, provide them with additional care and psychological assistance, and strive to enhance patients' ability to cope with pressure and consolidate their social support network.

Key words: colorectal cancer, operation, chemotherapy, rumination