Abstract: Objective To analyze the clinical features of nosocomial infection in a top three Chinese medicine hospital from 2019 to 2023. Methods The monitoring data of hospital feeling in Tai 'an Hospital of Traditional Chinese Medicine from 2019-2023 were collected retrospectively. The situation of nosocomial infection, underreporting of nosocomial infection, use of antibiotics, infection rate of Class Ⅰ incision and prophylactic antibiotics, multi-drug-resistant bacteria infection, incidence of three-tube related infections, distribution characteristics of nosocomial infection sites and departments were analyzed. Results From 2019 to 2023, the total number of inpatients in our hospital was 168 413, the number of nosocomial infections was 1 626, the incidence of infection was 0.97%, the number of nosocomial infections was 1757, and the rate of infection was 1.04%. The number of missed reports was 27, with a false report rate of 1.66%, and the number of missed reports was 27, with a false report rate of 1.54%.The number of multidrug-resistant bacteria was 198, the infection rate was 0.12%, the number of infection cases was 226, the infection rate was 0.13%. The number of users of antibiotics was 68 301 (40.56%). There were 8900 patients with Class Ⅰ incision surgery, 9 432 cases of operation, 14 cases of surgical site infection, and the infection rate was 0.16%. There were 4 606 cases of antibiotic prophylactic use, and the prophylactic use rate was 48.83%. The number of catheterization patients was 13 821, the total number of days was 127 026, the number of catheter-related infections was 275, the number of infections was 277, the infection rate was 2.18‰. The number of users of central vessel catheters was 1 168, the total number of days was 12 832, the number of central vessel catheter-related infections was 6, the number of infections was 6, and the infection rate was 0.47‰. There were a total of 1 757 nosocomial infections, among which the top 5 were lower respiratory tract infections (including ventilator-related infections), urinary tract infections (including urinary duct related infections), upper respiratory tract infections, bacteremia (including central vascular catheter-related infections) and gastrointestinal infections, accounting for 38.82%, 26.24%, 21.63%, 3.70% and 2.22%, respectively. The top 5 nosocomial infections were in the department of encephalopathy (including the ICU), the Department of intensive Care Medicine, the department of rehabilitation, the department of encephalopathy surgery and the Department of geriatrics, accounting for 23.33%, 19.52%, 7.63%, 7.40% and 6.49% respectively. A total of 226 cases of multidrug-resistant bacteria were nosocomial infections, and the top 5 departments of multidrug-resistant bacteria infection were intensive care medicine, encephalopathy surgery, rehabilitation, encephalopathy (including encephalopathy ICU), and geriatrics, accounting for 57.08%, 12.39%, 7.96%, 7.08%, 7.08%, respectively. The pathogen with the highest incidence was carbapenem-resistant Acinetobacter baumannii. The highest incidence sites were lower respiratory tract infection (including ventilator related) and urinary tract infection (including catheter related), 76.99% and 10.18%, respectively. Sputum, urine, puncture fluid and secretions and blood samples were the main samples for multidrug-resistant bacterial infection. Conclusion The incidence rate of nosocomial infection, the missing report rate and the infection rate of class Ⅰ incision are all up to standard. However, the situation of antibiotics in inpatients and the monitoring and prevention measures of multi-drug-resistant bacteria are still the key and difficult link in the management of nosocomial infection in the future.

Key words: hospital infection, infection rate, antimicrobial drugs, multi-drug resistant bacteria