Abstract: Objective Analyze the predictive value of homocysteine (Hcy) combined with serum miR-210-3p in cognitive dysfunction of patients with acute ischemic stroke. Methods A total of 97 patients with acute ischemic stroke who received treatment in Shouguang People's Hospital from July 2020 to July 2023 were selected as the study group, and the patients were divided into cognitive dysfunction (PSCI) group (n=38) and non-PSCI group (n=59) according to the results of the Montreal Cognitive Assessment Scale (MoCA). In addition, 100 healthy people who came to our hospital for physical examination at the same phase were regarded as the control group. Results The Hcy of the study group was higher than that of the control group, while the miR-210-3p was lower than that of the control group, (P<0.05);the Hcy of the SCI group was higher than that of the non-PSCI group, and the miR-210-3p was lower than that of the non-PSCI group(P<0.05). miR-210-3p (OR=0.469, P<0.05) may be an independent protective factor for cognitive dysfunction following acute ischemic stroke; whereas Hcy (OR=25.842, P<0.05) may be a risk factor contributing to cognitive dysfunction following acute ischemic stroke. The analysis of the ROC curve shows that the areas under the curve (AUC) for Hcy, miR-210-3p, and their combined detection are 0.791, 0.744, and 0.894, respectively. The ranking from highest to lowest is: combined detection>Hcy>miR-210-3p. The sensitivity and specificity of the combined detection were 87.80% and 94.10%. Conclusion Hcy combined with miR-210-3p can predict the occurrence of PSCI after acute ischemic stroke, and provide effective risk prediction for clinical treatment.

Key words: homocysteine, serum miR-210-3p, acute ischemic stroke, cognitive dysfunction, predictive value