Abstract: Objective To compare and analyze the efficacy of aspirin in different gestational weeks on high-risk pregnant women with preeclampsia, and to provide reference for pregnancy safety. Methods Eighty pregnant women with high risk of preeclampsia who received treatment in the department of obstetrics,Jiangyin Hospital Affiliated to Nantong University from September 2019 to September 2022 were selected as the main body and randomly divided into group A (28 cases), Group B (28 cases) and blank control group (24 cases, without taking aspirin). Patients in group A received 100 mg aspirin since the 12th week of gestation, and patients in group B received 100 mg aspirin since the 16th week of gestation. The drug was stopped at the 28th week of gestation in both groups, and the blood pressure control was 130-155/80-105mmHg. If the complication was organ dysfunction, the control was 130-139/80-89mmHg. Preeclampsia occurrence, pregnancy outcome, mode of delivery, neonatal related outcome and urine misfolded protein positive rate were compared among the three groups. Results There was no significant difference in the incidence of preeclampsia and adverse pregnancy outcomes between Group A and Group B (P>0.05); The incidence of preeclampsia and adverse pregnancy outcomes in Group A and Group B was lower than that in the control group(P<0.05). There was no significant difference in cesarean section rate and spontaneous labor rate between Group A and Group B (P>0.05); The cesarean section rate in Group A and Group B was lower than that in the control group, and the spontaneous delivery rate was higher than that in the control group (P<0.05). There was no significant difference in Apgar score and incidence of adverse neonatal outcomes between Group A and Group B (P>0.05); The Apgar of newborns in Group A and Group B was higher than that in the control group, and the incidence of adverse neonatal outcomes was lower than that in the control group (P<0.05). Urine misfolded protein positive rates in group A at 28 weeks and 32 weeks of pregnancy were significantly lower than those in control group, and the positive rate in group A was lower than that in group B (P<0.05). Conclusion Aspirin has a significant effect in the prevention of preeclampsia. Taking aspirin at 12 and 16 weeks of gestation in high-risk pregnant women can effectively reduce the incidence of preeclampsia, while also improving the rate of spontaneous labor and reducing the incidence of adverse maternal and infant outcomes.

Key words: aspirin, different gestational weeks, preeclampsia, high-risk pregnant women