Abstract: Objective This study aimed to construct a research project management model based on the theory of the entire life cycle and explore its application effects. Methods A qualitative-quantitative comprehensive research method was employed, with qualitative grounded theory research as the core, to establish a research project management model based on the theory of the entire life cycle. Quantitative research was also conducted to analyze changes in research project approval and output from 2019-2020 under different management modes and evaluate the quality and effectiveness of these modes. Results Under the new mode, there was a significant increase in the absolute number of approved research projects, with a trend towards younger project leaders. The numbers for reasonable use of project funds, on-time completion of projects, and output of research results increased by 887.50%, 167.74%, and 82.61% respectively, with statistically significant differences (P<0.05). Conclusion The research project management model based on entire life cycle theory can effectively guide the scientific research management work at municipal-level hospitals while improving both quality and efficiency in research projects,and is worth applying to hospitals at the same level.

Key words: municipal-level hospitals, research projects, entire life cycle management, grounded theory methodology, qualitative-quantitative mixed methods