Abstract: Objective To analyze the early adverse reactions of patients with differentiated thyroid cancer(DTC) after initial iodine-131 treatment and its influencing factors. Methods 106 patients who were treated with iodine-131 for the first time after DTC surgery in the nuclide treatment ward of Chifeng Municipal Hospital from January 2022 to December 2022 were retrospectively collected. Adverse reactions within 4 days after taking oral iodine-131 were recorded, and the influencing factors were analyzed by Logistic regression analysis. Results Among the 106 patients, 41 had neck swelling or pain, 36 had stomach discomfort or vomit, 32 had dry mouth or canker sores, 11 had abnormal taste, 10 had dry eyes, and 3 had chest tightness and shortness of breath. These adverse reactions were related to iodine absorption rate, iodine-131 dosage, TgAb level, postoperative stage and other multi-factors. The multiple factor regression equation of neck pain and swelling and its influencing factors was y = 2.223 × 4h iodine uptake rate + 20.802 × postoperative staging-28.689. The predictive accuracy of the equation was 86.8%. The multiple factor regression equation of the total adverse reaction was y = 0.084 × iodine dosage + 0.597 × 24h iodine uptake rate-11.499. The predictive accuracy of the equation was 82.1% . Conclusion Early adverse reactions of DTC patients after iodine-131 treatment have some clear influencing factors, and early drug or nursing intervention can be carried out to reduce the occurrence of early adverse reactions.

Key words: thyroid cancer surgery, iodine-131 therapy, adverse reactions