Abstract: Objective To explore the feasibility and safety of early ambulation in patients after the percutaneous renal biopsy. Methods Relevant randomized controlled trials(RCTs)were collected using databases of China National Knowledge Infrastructure(CNKI), VIP, Wanfang Database, CBM, PubMed, Cochrane Library, Emba-se, Web of Science from inception of databases to April 2024. Quality evaluation of the included literature were performed. Data were analyzed with Revman 5.3 software. Results Thirteen studies were recruited, including 9 RCTs and 4 CCTs, and 2125 patients were analyzed. The Meta-analysis showed that compared with bed rest,early ambulation reduced the incidence of uroschesis in patients after the percutaneous renal biopsy[early activity: 51/368; bed rest: 151/559; RR=0.44, 95%CI (0.22, 0.91), the incidence of low back discomfort[early activity: 118/637; bed rest: 265/941; RR=0.52, 95%CI(0.43,0.61)], and the incidence of sleep disorder[early activity: 15/92; bed rest: 41/92; RR=0.37, 95%CI(0.22, 0.60)]. There were no statistically significant difference on gross hematuria and perirenal hematoma in patients after the percutaneous renal biopsy. Conclusion Early ambulation did not increase the incidence of gross hematuria and perirenal hematoma in patients after the percutaneous renal biopsy compared with bed rest. However, it can reduce uroschesis in patients after the percutaneous renal biopsy. Besides, early ambulation would be propitious to increase comfort of patients．

Key words: percutaneous renal biopsy, early Ambulation, meta-analysis