Abstract: Objective To explore and analyze the clinical efficacy and safety of Yiqing Capsules combined with Viamine Capsules in the treatment of oral lichen planus. Methods A random number table method was used to group 238 cases of lichen planus admitted to Department of Stomatology, Jiaozhou Hospital from April 2020 to February 2024, with 119 cases in each group. The control group was treated with vitamin E capsules, while the observation group was treated with Yiqing capsules. The two groups were treated continuously for 3 months. The efficacy, pain degree, lesion area and inflammatory response were compared between the two groups, and the adverse reactions were compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group. Compared with the control group after treatment, the VAS score of observation group was lower, the lesion area was reduced, and the serum levels of SP, IL-8 and IL-12 were lower, with statistical significance (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion The combination of Yiqing capsule and viaminate capsule showed a higher clinical total effective rate of oral lichen planus, which can promote the regulation and improvement of symptoms and signs of patients, reduce the pain caused by the disease, shrink the lesion site, and also regulate the levels of serum SP, IL-8 and IL-12 during treatment, so as to obtain a better prognosis. The overall security is also high.

Key words: Yiqing Capsules, Vitamin ester capsules, oral lichen planus, therapeutic effect, security