Abstract: Objective To explore the effects of modified Huangqi Ramulus Cinnamomi Wuwu decoction on shoulder joint function, inflammatory factors, and serum 5-HT, PGE2 in patients with periarthritis of the shoulder. Methods 80 patients with periarthritis of the shoulder admitted to Xi 'an Yanliang District People's Hospital from February 2022 to February 2023 were selected as the study subjects, and they were divided into an observation group and a control group using a random number table method, with 40 patients in each group. The control group received routine treatment, while the observation group received modified Huangqi Ramulus Cinnamomi Wuwu decoction on the basis of the control group. The Constant-Murley score and Visual Simulation Scale (VAS) were used to evaluate the functional changes of the shoulder joint before and after treatment, and the levels of inflammatory factors and the expression of 5-hydroxytryptamine (5-HT) and prostaglandin E2 (PGE2) in the serum were compared. Results Before treatment, there was no significant difference in the shoulder joint function score and pain score between the two groups (P>0.05). After treatment, the shoulder joint function score of the two groups of patients increased, and the observation group was higher than the control group, while the pain score was lower, and the observation group was lower than the control group (P<0.05); There were no significant differences in the levels of TNF-α, TGF-β1, WBC and CRP between the two groups before treatment (P>0.05). After treatment, the levels of TNF-α, TGF-β1, WBC and CRP in the two groups were decreased, and the observation group was lower than the control group (P<0.05). Before treatment, there was no significant difference in 5-HT and PGE2 between the two groups (P>0.05), and after treatment, 5-HT and PGE2 of the two groups were decreased, and the observation group was lower than the control group (P<0.05). Conclusion Increasing modified Huangqi Ramulus Cinnamomi Wuwu decoction to patients with periarthritis of the shoulder on the basis of routine treatment can improve the function of the shoulder joint, reduce the degree of pain, and alleviate the level of inflammatory reaction in the body. The therapeutic mechanism may be related to the reduction of serum 5-HT and PGE2, which is worthy of clinical application.

Key words: Modified Huangqi Ramulus Cinnamomi Wuwu decoction, scapulohumeral periarthritis, inflammatory factors, joint function, 5-hydroxytryptamine, prostaglandin E2