Abstract: Objective To explore the predictive value of Superoxide dismutase (SOD), Glutathione peroxidase (GSH Px), Malondialdehyde (MDA), Myeloperoxidase (MPO) and epilepsy after cerebrovascular disease. Methods 180 patients with Cerebrovascular disease admitted to Helan County People's Hospital from June 2018 to June 2023 were selected as the study subjects. They were divided into epilepsy group (n=28) and non epilepsy group (n=152) according to whether epilepsy occurred after the occurrence of cerebrovascular disease. In addition, 30 healthy volunteers who came to Helan County People's Hospital for physical examination at the same time were selected as the control group. Compare the expression levels of SOD, GSH-Px, MDA, and MPO among three groups of subjects, and use logistic regression analysis to analyze the predictive value of SOD, GSH-Px, MDA, and MPO for the occurrence of epilepsy after cerebrovascular disease. Subsequently, 28 patients with epilepsy after cerebrovascular disease were divided into two subgroups based on the type of seizure, namely the partial seizure group (n=15) and the systemic tetanic spasm group (n=13). And Spearman correlation analysis was used to analyze the correlation between SOD, GSH-Px, MDA and MPO and seizure severity after cerebrovascular disease. Result The levels of SOD and GSH-Px in the epilepsy group were significantly lower than those in the non epilepsy group and control group, while the levels of MDA and MPO were significantly higher than those in the non epilepsy group and control group (P<0.05); Logistic regression analysis showed that the decrease of SOD, GSH Px and the increase of MDA and MPO were independent factors influencing Seizure after cerebrovascular disease (P<0.05); The levels of SOD and GSH-Px in patients with generalized tonic spasm were lower than those in the partial seizure group, while the levels of MDA and MPO were higher than those in the partial seizure group (P<0.05); The Spearman correlation analysis results showed that SOD, GSH-Px were negatively correlated with the severity of epilepsy after cerebrovascular disease, while MDA, MPO were positively correlated with the severity of epilepsy after cerebrovascular disease (P<0.05). Conclusion The observation of serum SOD, GSH Px, MDA, MPO levels can predict the occurrence of epilepsy after cerebrovascular disease, and the lower the level of SOD, GSH Px and the higher the level of MDA, MPO, the more serious the seizure in patients with such cerebrovascular disease. Therefore, in clinical practice, relevant measures should be taken in time to prevent epilepsy and reduce the severity of seizure after cerebrovascular disease.

Key words: cerebrovascular disease, epilepsy, superoxide dismutase, glutathione peroxidase, malondialdehyde, myeloperoxidase