Abstract: Objective To investigate the efficacy of transurethral holmium laser resection of bladder tumors in patients with non muscle invasive bladder cancer, and analyze the factors affecting postoperative recurrence. Methods A total of 100 patients with non muscle invasive bladder cancer who received treatment in Bortala Mongol Autonomous Prefecture People's Hospital were screened out. The relevant medical data were collected from May 2017 to May 2021, and were retrospectively analyzed. They were grouped according to the operation mode. 50 patients were set as the observation group and underwent transurethral holmium laser resection of bladder tumors. The other 50 patients were included in the control group and underwent transurethral plasma resection of bladder tumors. Perioperative indicators, complications and recurrence rates of the two groups were compared. Subsequently, the patients were divided into two subgroups based on their recurrence status within 2 years, namely the recurrence group (n=19) and the non recurrence group (n=81), and the influencing factors of recurrence were analyzed. Results There was no significant difference in surgical time between the two groups of patients (P>0.05). The observation group had significantly lower urinary catheter indwelling and postoperative hospital stay, incidence of complications, and recurrence rate compared to the control group (P<0.05); There were significant differences in TNM staging, surgical methods, degree of tissue differentiation, and number of tumors between the non recurrent group and the recurrent group (P<0.05); The results of Logistic regression analysis showed that TNM stage, operation mode and tissue differentiation were independent influencing factors for postoperative recurrence of non muscle invasive bladder cancer (P<0.05). Conclusion For patients with nonmuscular invasive bladder cancer, transurethral holmium laser resection of bladder tumor has a lower degree of injury, can promote early recovery, and can reduce the incidence of complications and recurrence. In addition, TNM staging, operation mode and tissue differentiation degree are independent factors affecting the recurrence of non muscle invasive bladder cancer after surgery. Therefore, more attention should be paid to patients with low TNM staging and tissue differentiation, and transurethral holmium laser resection of bladder tumors should be selected as far as possible.

Key words: transurethral holmium laser resection of bladder tumor, transurethral plasmakinetic resection of bladder tumor, non muscle invasive bladder cancer, recurrence rates, influence factor