Abstract: Objective To investigate the effect of ginkgolone ester drops combined with metoprolol in the treatment of heart failure in dilated cardiomyopathy and its effect on ventricular remodeling. Methods The case data of 120 patients with heart failure with dilated cardiomyopathy admitted to Inner Mongolia Autonomous Region People's Hospital were analyzed (January 2019 to December 2022), and divided into control group (n=60) and observation group (n=60) by random number table method. Both groups continued treatment for 6 weeks. Comparing the treatment effect, cardiac function [left ventricular end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF)], inflammatory factor level [N-terminal brain natriuretic peptide precursor (NTpro-BNP), tumor necrosis factor α (TNF-α), hypersensitivity C-reactive protein (hs-CRP), ventricular remodeling function [serum matrix metalloproteinase-9 (MMP-9), type I precollagen amino-terminal peptide (PI.NP), type III precollagen amino-terminal peptide (PIII.NP)] and the occurrence of adverse effects. Results The total effective rate of treatment in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the LVEDD level in both groups was significantly reduced, and the decrease was greater in the observation group than in the two groups, with a statistically significant difference (P<0.05), and the LVEF level in both groups was significantly increased, and the increase in the observation group was greater than that in the two groups, and the difference was statistically significant (P<0.05). After treatment, the levels of NTpro-BNP, TNF-α and hs-CRP were reduced in both groups, and the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). After treatment, the levels of PI.NP, PIII.NP and MMP-9 were reduced in both groups, and the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Ginkgolone ester drops combined with metoprolol have a significant effect in the treatment of dilated cardiomyopathy heart failure, which can improve cardiac function, reduce inflammatory response and inhibit ventricular remodeling.

Key words: dilated cardiomyopathy heart failure, metoprolol, ginkgolone ester drop pills, cardiac function, inflammatory factors