Abstract: Objective To explore the effects of Five-tone therapy on anxiety, depression and quality of life in snake bites. Methods A total of 106 snake bite patients admitted to the emergency department of a Grade A TCM hospital in Anhui province from January ,2022 to July ,2023 were selected and divided them into observation and control groups according to the random number table method, with 53 cases in each group. Both groups were given basic drug therapy and routine care, and the observation group took Five-tone therapy on this basis. Before treatment and after discharge were assessed using the Anxiety Self Assessment Scale (Self-Rating Anxiety Scale SAS) and Depression Self Assessment Scale (Self-rating depression scale, SDS) and the Dingham Health Questionnaire (nottingham health profile, NHP). Results The observed group was significantly lower than the control group in both SAS and SDS scores, the NHP score lower than the control group,and the difference was statistically significant (P<0.05). Conclusion The application of Five-tone therapy in the treatment of snake bite patients can help reduce negative emotions and promote the improvement of quality of life.

Key words: snake bite, five-tone therapy, anxiety, depression, negative mood, quality of life