Abstract: Objective To investigate the effect of vitamin C combined with cimetidine on the prognosis of children with Henoch Schonlein purpura and the impact on allergens and kidney damage. Methods A total of 80 cases of children with Henoch Schonlein purpura in Shuyang hospital from January 2020 to December 2022 were selected and analyzed. They were divided into observation group and control group by lottery, with 40 cases in each group. The control group received conventional symptomatic treatment. The observation group was treated with vitamin C combined with cimetidine on the basis of the control group. The levels of interleukin-18 (IL-18), D-Dimer (D-D) and fibrinogen (FIB) related prognostic indicators in the two groups were compared, and the positive rates of allergen specific IgE antibodies in the two groups were detected before and after treatment, and the expression levels of urine routine related renal damage indicators in the two groups were compared before and after treatment. Results There was no significant difference in the levels of IL-18, D-D and FIB related prognostic indicators between the two groups before treatment (P>0.05). After treatment, the levels of IL-18, D-D and Fib in the two groups decreased, and the observation group was lower than the control group (P<0.05); There was no significant difference in the positive rate of IgE antibody between the two groups(P>0.05). After treatment, the positive rate of allergen specific IgE antibody in the observation group was lower than that in the control group(P<0.05); There was no significant difference in the levels of urinary white blood cells, urinary red blood cells and positive rate of urinary protein between the two groups before treatment (P>0.05). After treatment, the levels of urinary white blood cells, urinary red blood cells and positive rate of urinary protein in the two groups were reduced, and the observation group was lower than the control group (P<0.05). Conclusion Vitamin C combined with cimetidine can significantly improve the prognosis of children with Henoch Schonlein purpura, reduce the positive rate of allergen specific IgE antibody detection, and reduce the degree of renal damage.

Key words: Vitamin C, cimetidine, children, allergic purpura, allergens