Abstract: Objective To explore the clinical effect of minimally invasive gastric cancer surgery in patients with gastric cancer. Methods From June 2019 to January 2022, 100 patients with gastric cancer who were diagnosed with gastric cancer in Jining First People’s Hospital and had surgical indications were included as the analysis objects, and the patients were divided into groups according to the differences in surgical treatment plans. The 50 patients who received surgical intervention were set as the laparotomy group, and the 50 patients who received laparoscopic minimally invasive assisted radical gastrectomy for gastric cancer were set as the minimally invasive group. The perioperative indicators, serological indicators, and postoperative complication rates of gastric cancer patients after two surgical treatments were used to evaluate the clinical value of minimally invasive methods. Results The time required for surgery in the minimally invasive group was significantly longer than that in the laparotomy group, while the incision length, intraoperative blood loss, and postoperative exhaust time were significantly lower than those in the laparotomy group (P<0.05). After the operation, the white blood cells (WBC) and superoxide dismutase (SOD) of the patients in the two groups were significantly lower than those in the laparotomy group (P<0.05). The incidence of surgery-related complications before discharge in the minimally invasive group was significantly lower than that in the open group (P<0.05). Conclusion Minimally invasive gastric cancer surgery requires higher professional quality of equipment and operators, but it can effectively control the degree of trauma to the patient’s body. In terms of long-term efficacy, there is no significant difference from laparotomy, but the patient’s acceptance is higher, to improve overall comfort.

Key words: gastric cancer, Laparoscopic minimally invasive surgery, perioperative indicators, Long term effect