Abstract: Objective To observe the clinical effect of high and low frequency repetitive transcranial magnetic stimulation (rTMS) on patients with post stroke cognitive impairment (PSCI). Methods 60 PSCI patients hospitalized in Jiangsu Civil Affairs Rehabilitation Hospital and the Second Affiliated Hospital of Nanjing Medical University from March 2017 to March 2022 were selected and divided into treatment group and control group according to random number table.There were 30 patients in each group. The control group was treated with oral memantine hydrochloride tablets and conventional rehabilitation therapy. The treatment group was treated with high and low frequency rTMS on the basis of the control group. Before and after treatment, the patients were evaluated with Mini mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and modified Barthel index (MBI), and the data were recorded and analyzed statistically. Results After treatment, the MMSE scores of patients in the treatment group were higher than those in the control group, with a statistically significant difference (P<0.05); after treatment, the Moca score of patients in the treatment group was higher than that in the control group, with a statistically significant difference (P<0.05); after treatment, the MBI score of the treatment group was higher than that of the control group, with a statistically significant difference (P<0.05). Conclusion High and low frequency rTMS alternative treatment can improve the cognitive function of PSCI patients more quickly and improve the ability of daily living, which is worthy of further clinical application.

Key words: post-stroke cognitive impairment, repetitive transcranial magnetic stimulation, mini-mental state examination, montreal cognitive assessment, modified barthel index