Clinical Observation of Bronchoscopic Alveolar Lavage Combined with Inhalation of Acetylcysteine Solution in Patients with Severe Pneumonia

Abstract

Abstract: Objective To investigate the effects of bronchoscopic alveolar lavage combined with inhalation of acetylcysteine solution on blood gas indexes and pulmonary ventilation function in patients with severe pneumonia. Methods 80 patients with severe pneumonia admitted to First People's Hospital of Pingyuan County from January to December 2021 were selected and randomly divided into groups. The control group (n=40) received bronchoscopic alveolar lavage, while the other (n=40) received inhalation of acetylcysteine solution for intervention. The total effective rate and clinical indicators of the two groups were compared. Results The total effective rate of treatment in the observation group was higher than that in the others, with a statistically significant difference (P<0.05). After treatment, the partial pressure of oxygen in the observation group was higher than those, and the partial pressure of carbon dioxide was lower than the others. The levels of FEV₁, FEV₁/FVC, and PEF in the first second were significantly higher than those in the others (P<0.05). After treatment, the PCT and interleukin IL-6 in the observation group were lower on average than those in the control group, and the levels of IL-10 were higher than those in the control group, with a statistically significant difference (P<0.05). Conclusion The treatment of severe pneumonia patients with bronchoscopic alveolar lavage combined with inhalation of acetylcysteine solution has a definite effect, and can alleviate the body's inflammatory reaction.

Key words: severe pneumonia, bronchoscope, alveolar lavage, pulmonary ventilation function

CLC Number:

R563.1

SUN Feng-jiao, MA Wei-wu. Clinical Observation of Bronchoscopic Alveolar Lavage Combined with Inhalation of Acetylcysteine Solution in Patients with Severe Pneumonia[J]. ZHONGHUA YANGSHENG BAOJIAN, 2023, 41(19): 8-11.

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