Abstract: Objective To explore and analyze the value of echocardiography parameter integration system in the risk assessment of prognosis of patients with heart failure at high altitude. Method From August 2020 to July 2022, 76 patients with heart failure in high-altitude areas who were treated in Maqin County People's Hospital were selected as research objects. All patients were given cardiac ultrasound examination, routine ultrasound indexes were recorded, and cardiac ultrasound parameter integrals were determined. Patients were divided into adverse and non-adverse cardiovascular events according to the follow-up results. Spearsman analysis and COX regression analysis were performed to follow up the prognosis of patients, and ROC curve was drawn for risk assessment and analysis. Results After six months of follow-up, major cardiovascular adverse events occurred in 16 of 76 patients (adverse group). There were no significant differences in gender, age, body mass index, systolic blood pressure, diastolic blood pressure, NYHA grade and primary disease in the adverse group compared with the non-adverse group (P>0.05). The score of cardiac ultrasound parameters in the adverse group which was significantly higher than that in the non-adverse group (P<0.05). The left atrial diameter, left ventricular end-diastolic diameter, left ventricular end-systolic diameter and early diastolic blood flow velocity in the poor group were higher than those in the non-adverse group (P<0.05), while the late diastolic blood flow velocity, left ventricular ejection fraction and stroke output in the poor group were lower than those in the non-adverse group (P<0.05). Among 76 patients, Spearsman analysis showed that early diastolic blood flow velocity and cardiac ultrasound parameter integral were positively correlated with prognostic major cardiovascular adverse events, while late diastolic blood flow velocity was negatively correlated with prognostic major cardiovascular adverse events (P<0.05). Multivariate COX regression analysis showed that early diastolic blood flow velocity, late diastolic blood flow velocity and cardiac ultrasound parameter integral were all important factors affecting the prognosis of patients with major cardiovascular adverse events (P<0.05). ROC curve analysis showed that the area under the curve of risk assessment of heart failure patients at high altitude was 0.889. Conclusion Major cardiovascular adverse events are likely to occur in patients with heart failure at high altitude during the prognosis process, which can lead to abnormal cardiac ultrasound parameter integration. Cardiac ultrasound parameter integration system has a good risk assessment value for the prognosis of patients with heart failure at high altitude, and has high clinical practical value.

Key words: cardiac ultrasound parameter integration system, high altitude area, heart failure, prognosis evaluation, early diastolic blood flow velocity, late diastolic blood flow velocity