Abstract: Objective To explore and analysis the risk factors of insulin antibody production in type 2 diabetes patients in Hotan area. Methods A total of 213 patients with type 2 diabetes hospitalized in the Endocrinology Department of Hotan District People's Hospital from April 1, 2021 to September 30, 2022 were selected to detect serum insulin antibody expression levels, and were divided into positive and negative groups according to the test. Results The general information, blood biochemical indexes and dynamic blood glucose indexes of all patients were investigated. Pearson was used to analyze the correlation between positive insulin antibody and 24 h blood glucose standard deviation, 24 h maximum blood glucose fluctuation range, 24 h mean blood glucose fluctuation range, low density lipoprotein and total cholesterol in type 2 diabetes patients. Logistic regression was used to analyze the risk factors of positive insulin antibody in type 2 diabetes patients. Results In 213 cases Among the patients, 4 patients were positive for serum insulin antibody, the resistance rate was 1.88%. There were no significant difference compared between the positive group and the negative group in triglycerides, fasting blood glucose, high-density lipoprotein (P>0.05), while the positive group had significantly higher levels of low-density lipoprotein, total cholesterol (P<0.05). There were no significant difference compared between the two groups in the comparison of 24 h mean blood glucose (P>0.05). The standard deviation of 24 h blood glucose, the maximum fluctuation range of 24 h blood glucose, and the fluctuation range of 24 h mean blood glucose in the positive group were significantly higher than those in the negative group (P<0.05). Pearson analysis showed that the positive correlation serum insulin antibody of type 2 diabetes patients in Hotan area were correlated with the standard deviation of 24 h blood glucose, the maximum amplitude of 24 h blood glucose fluctuation, the average amplitude of 24 h blood glucose fluctuation, low-density lipoprotein, total cholesterol (r=0.862、0.707、0.597、0.655、0.601, P<0.05). Logistic regression analysis showed that 24 h standard deviation of blood glucose, 24 h maximum fluctuation range of blood glucose, 24 h average fluctuation range of blood glucose, low-density lipoprotein and total cholesterol were all risk factors for insulin antibody production in type 2 diabetes patients in Hotan area (P<0.05). Conclusion The proportion of insulin antibody production in type 2 diabetes patients in Hotan area is relatively low, but it still exists. The fluctuation of blood lipid and blood sugar is an important risk factor for insulin antibody production in type 2 diabetes patients in Hotan area.

Key words: Hotan area, type 2 diabetes, insulin antibody, 24 h mean blood glucose fluctuation range, low density lipoprotein, risk factors