Abstract: Objective To observe the effect of Jiawei Qingzhong Decoction combined with desensitization on allergic conjunctivitis. Methods A total of 100 patients with allergic conjunctivitis (from March 2020 to March 2022) admitted to Miyun Hospital, the Third Affiliated Hospital of Beijing University of Chinese Medicine were selected and divided into control group (50 cases) and observation group (50 cases). The control group was treated with desensitization, and the observation group was treated with Jiaweiqingzhong Decoction on the basis of desensitization treatment. The therapeutic effect, inflammatory factors, tear film function and clinical symptoms were observed. Results The effective rate of observation group was higher than that of control group (P<0.05). The levels of IL-5, IL-4, IL-8 and TNF-α were not significantly different between the two groups before treatment (P>0.05). The levels of IL-5, IL-4, IL-8 and TNF-α were all decreased between the two groups after treatment, and the above indexes in the observation group were reduced more than that in the control group after treatment. The differences were statistically significant (P<0.05). Before treatment, there was no significant difference in the levels of FL, SIt and BUT between the two groups (P>0.05). After treatment, the levels of FL decreased and SIt and BUT increased between the two groups, and the change range of the above indexes in the observation group was greater than that in the control group. The differences were statistically significant (P<0.05). Before treatment, there was no statistical significance in symptom scores of conjunctival congestion, increased secretions, ocular oxygen and tears between the two groups (P>0.05). After treatment, symptom scores of conjunctival congestion, increased secretions, ocular oxygen and tears between the two groups were decreased, and after treatment, the above index scores of the observation group were lower than that of the control group. The differences were statistically significant (P<0.05). Conclusion Jiawei Qingzhong Decoction combined with desensitization treatment for patients with allergic conjunctivitis can improve the therapeutic effect, reduce inflammation, promote the improvement of tear film function and clinical symptoms, which is worth reference.

Key words: Jiawei Qingzhong Soup, desensitization, allergic conjunctivitis, efficacy, inflammatory factor