Abstract: Objective To investigate the application effect of carotid artery stenting in patients with acute internal carotid artery system cerebral infarction and moderate to severe stenosis of ipsilateral internal carotid artery. Methods The clinical data of 40 patients with acute internal carotid system cerebral infarction and ipsilateral internal carotid artery moderate to severe stenosis admitted to Binzhou Central Hospital from June 2019 to June 2021 were retrospectively analyzed into two groups. Twenty-five patients who received conventional dual-antibody+basic medical treatment were the control group, and 15 patients who received conventional dual-antibody+basic medical treatment+carotid stent implantation were the observation group. Both groups were followed up for 6 months. The cerebral hemodynamics, neurological function, cognitive function, quality of life and recurrence of cerebral infarction were compared between the two groups. Results Before treatment, resistance index (RI), maximum systolic blood flow velocity (Vs), mean blood flow velocity (Vm), National Institutes of Health Stroke Scale (NIHSS), Mini-Smart Scale (MMSE), There was no significant difference in the scores of each dimension in Montreal Cognitive Assessment Scale (MoCA) and Quality of Life Comprehensive Assessment Questionnaire (GQOLI-74) (P>0.05). After treatment, the RI and NIHSS scores in the two groups were lower than Before treatment, the scores of each dimension in Vs, Vm, MMSE, MoCA and GQOLI-74 were higher than those before treatment, and the RI and NIHSS scores in the observation group were lower than those in the control group. The score was higher than that in the control group, and the difference was statistically significant (P<0.05). The recurrence rate of cerebral infarction in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Carotid artery stenting can effectively improve cerebral hemodynamics in patients with acute internal carotid artery system cerebral infarction and ipsilateral internal carotid artery moderate-severe stenosis, which is beneficial to the recovery of neurological function, improving cognitive function and life. Quality improvement, effective prevention of recurrence of cerebral infarction.

Key words: carotid artery stenosis, cerebral infarction, carotid artery stenting, cerebral hemodynamics, cognitive function