ZHONGHUA YANGSHENG BAOJIAN ›› 2023, Vol. 41 ›› Issue (1): 1-4.

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The Efficacy of Repeated Transcranial Magnetic Stimulation in the Treatment of Chronic Insomnia and the Improvement of Cognitive Function and Bad Mood

LU Yi1, WANG Wei1, MI Guo-lin2, JIAN Jia3, ZHENG Yun-shao4, LIU Jin-tong5   

  1. 1. Department of Physical Therapy, Shandong Mental Health Center, Jinan Shandong 250014, China;
    2. Department of Psychosomatic Medicine, Shandong Mental Health Center, Jinan Shandong 250014, China;
    3. Department of Psychiatry I, Shandong Mental Health Center, Jinan Shandong 250014, China;
    4. Department of Psychiatry V, Shandong Mental Health Center, Jinan Shandong 250014, China;
    5. Department of Psychological Behavior of Children and Adolescents I, Shandong Mental Health Center, Jinan Shandong 250014, China
  • Online:2023-01-01 Published:2023-01-06

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Abstract: Objective To investigate the efficacy of repetitive transcranial magnetic stimulation (rTMS) in the treatment of chronic insomnia and the improvement of cognitive function, sleep quality, sleep belief and attitude. Methods A total of 240 patients with chronic insomnia who met the inclusion criteria and were treated in the Shandong Mental Health Center from January to December 2019 were selected as the research objects. They were randomly divided into left dorsolateral prefrontal cortex (DLPFC) treatment group, right DLPFC treatment group, 1 cm behind the central point (Cz) treatment group and control group (sham stimulation group), with 60 cases in each group. Pittsburgh sleep quality index (PSQI) and sleep personal belief and attitude scale (DBAS) were used to evaluate the patients’ sleep quality, sleep belief and attitude before and at the end of treatment. The cognitive function of patients was evaluated in neuropsychological and electrophysiological aspects by Montreal Cognitive Assessment Scale (MoCA), symbol number conversion test (SDMT) and event-related potentials (ERPs). Results The PSQI scores of left DLPFC treatment group, right DLPFC treatment group and 1 cm after Cz treatment group were significantly lower than those before treatment, and the DBAS scores were significantly higher than those before treatment (P<0.05). There was no significant difference between PSQI and DBAS before and after treatment in the control group (P>0.05). The PSQI and DBAS of right DLPFC treatment group were significantly lower than those of left DLPFC treatment group and 1 cm after CZ treatment group; MoCA and SDMT in the left DLPFC treatment group, the right DLPFC treatment group and the treatment group 1 cm after CZ were significantly higher than those before treatment (P<0.05), but there was no significant difference in MoCA and SDMT before and after treatment in the control group (P>0.05); The P3 latency after treatment was significantly shorter in the left DLPFC treatment group, the right DLPFC treatment group and the treatment group 1 cm after CZ, and the P3 amplitude was significantly greater than that before treatment (P<0.05). There was no significant difference in P3 latency and P3 amplitude before and after treatment in the control group (P>0.05). Conclusion rTMS can greatly improve the cognitive function, sleep quality, sleep belief and attitude of patients, and the effect is significant. It is worthy to be applied in clinic.

Key words: repetitive transcranial magnetic stimulation, chronic insomnia, cognitive function, bad mood, curative effect

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