Abstract: Objective To study the effect of dapoxetine hydrochloride on sperm quality and psychological stress in patients with premature ejaculation. Methods One hundred and ninety patients with premature ejaculation admitted to Bethune Hospital in Shanxi Province from June 2018 to June 2021 were selected as the research objects, and were randomly divided into control group (95 cases) and observation group (95 cases). The control group was given sertraline hydrochloride tablets, and the observation group was given dapoxetine hydrochloride tablets. Both groups were treated continuously for 2 months. The scores of self-rating anxiety scale (SAS), self-rating depression scale (SDS), Intra-vaginal ejaculation latency time (IELT), scores of premature ejaculation scale and semen related indexes were compared before treatment and two months after treatment. Results After 2 months of treatment, the scores of SAS and SDS in the observation group were lower than those in the control group, the difference was statistically significant (P<0.05). After 2 months of treatment, IELT in the two groups was higher than that before treatment, after 1 month of treatment, after 1 month of treatment, and after 2 months of treatment, IELT in the observation group was higher than that in the control group, the difference was statistically significant (P<0.05). After 2 months of treatment, the scores of sexual satisfaction, ejaculation control ability, communication difficulty between partners and negative emotion related to premature ejaculation in the two groups were higher than those before treatment, and the scores in the observation group were higher than those in the control group, the difference was statistically significant (P<0.05). Compared with before treatment, after 2 months of treatment, there was no significant difference in total sperm count, sperm density and percentage of forward motility sperm between the two groups (P>0.05). Conclusion Sertraline hydrochloride and dapoxetine hydrochloride can improve sperm quality in patients with premature ejaculation, but dapoxetine hydrochloride can alleviate psychological stress and improve ejaculation control ability, which is helpful to improve sexual life quality of patients.

Key words: premature ejaculation, sertraline hydrochloride, dapoxetine hydrochloride, sperm quality, psychological stress