Abstract: Objective To study the clinical effect of compound α-ketoacid combined with atorvastatin in the treatment of chronic renal failure. Methods A total of 860 patients with chronic renal failure admitted to Panjin Liaoyou Baoshihua Hospital from January 2019 to December 2021 were retrospectively selected and divided into observation group and control group according to different treatment methods, with 430 cases in each group. Both groups adopted low protein diet to control blood pressure and blood glucose; the observation group was treated with compound alpha-ketoacid combined with atorvastatin. The two groups were treated for 2 months,and the clinical effects of the two groups were compared. Serum urea nitrogen(BUN),,serum creatinine (Scr),,cholesterol (TC),,albumin (ALB),,triglyceride (TG),,serum calcium,parathyroid hormone (PTH) and serum phosphorus in the two groups before and after treatment were detected level. Results The effective rate of the observation group was significantly higher than control group(P<0.05). Before treatment, there was no significant difference in SCR, bun, TG and TC between the two groups (P>0.05). After treatment,,SCR,,BUN, TG and TC decreased significantly(P<0.05), ALB increased significantly (P<0.05), and SCR, bun, TG and TC in the observation group were significantly lower than those in the control group(P<0.05), ALB was significantly higher than those in the control group (P<0.05). Before treatment, there was no significant difference in the levels of blood calcium, PTH and blood phosphorus between the two groups(P>0.05). After treatment, there was no significant change in the levels of blood calcium, PTH and blood phosphorus in the two groups (P>0.05). Conclusion Compound alpha-ketoacid combined with atorvastatin can effectively protect renal function, reduce blood phosphorus, increase blood calcium content, inhibit PTH secretion, and effectively delay the process of renal failure.

Key words: compound α-ketoacid, atorvastatin, chronic renal failure