the Association of Morning Serum Cortisol with Glucose Metabolism and Islet β-cell Function in Patients with Type 2 Diabetes Mellitus

Abstract

Abstract: Objective To observe the morning serum cortisol levels in patients with type 2 diabetes mellitus (T2DM), patients with first-diagnosed and untreated type 2 diabetes mellitus (T2DM) and healthy controls, and to analyze the relationship between serum cortisol and glucose metabolism and islet β-cell function. Methods 59 patients with T2DM were selected and 26 patients were diagnosed as T2DM for the first time and did not treated in Taixing people’s Hospital affiliated to Bengbu Medical College from September 2019 to September 2020, and 34 healthy adults matched in age and sex were selected as the control group. In the morning, fasting venous blood samples were collected to detect glycosylated hemoglobin (HbA1c), blood glucose (FPG), insulin (FINS), C-peptide and cortisol, and insulin resistance index (HOMA-IR) and islet β-cell function (HOMA- β) were calculated by steady-state model formula. All data were processed by statistical software MedCalc 15.2.2. Results ANOVA analysis showed that there was significant difference in morning serum cortisol levels among groups(P<0.05); Student-Newman-Keuls test showed that morning serum cortisol levels in first-diagnosed and untreated T2DM group were significantly higher than those in T2DM group and healthy control group (P<0.05); Mann-Whitney test showed that morning serum cortisol level in HbA1c<7.0% group was significantly lower than that in HbA1c>7.0% group (P< 0.05). In patients with T2DM, Spearman correlation analysis showed that serum cortisol level in the morning was positively correlated with FPG and HbA1c, and negatively correlated with HOMA- β, but no correlation was found between serum cortisol level and age, FINS, C-peptide and HOMA-IR. Conclusion There is a correlation between early morning serum cortisol and many glucose metabolic indexes in patients with T2DM, including fasting blood glucose, HbA1c and islet β-cell function, and there is a higher level of cortisol in patients with poorly controlled T2DM and first-diagnosed and untreated T2DM.

Key words: type 2 diabetes mellitus, cortisol, resistance index, β-cell function of islet, association

CLC Number:

R193

DI Yan-an, WANG Zhi-yong, DONG Lin, SHANG Wei, WANG Feng. the Association of Morning Serum Cortisol with Glucose Metabolism and Islet β-cell Function in Patients with Type 2 Diabetes Mellitus[J]. ZHONGHUA YANGSHENG BAOJIAN, 2022, 40(12): 4-8.

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