Abstract: Objective To explore and analyze the diagnostic value of retinal thickness combined with central retinal blood flow velocity in patients with non-proliferative type 2 diabetic retinopathy. Methods From February 2019 to June 2021, used the simple random sampling method, 122 cases of patients with non-proliferative type 2 diabetic retinopathy who were diagnosed and treated in Foshan Hospital of Traditional Chinese Medicine Sanshui Hospital, were selected as then on-proliferative group. And the other 122 cases with proliferative type 2 diabetic retinopathy in Department of Ophthalmology, Foshan Hospital of Traditional Chinese Medicine Sanshui Hospital, during the same period were selectedas the proliferative group. The retinal thickness was detected by optical coherence tomography (OCT), and the blood flow velocity of the central retinal blood vessels was detected by color Doppler diagnostic instrument,the correlation, influencing factors and diagnostic value was analyzed. Results The retinal MRT and CMT in the non-proliferative group were significantly lower than those in the proliferative group, the difference is statistically significant (P<0.05). The maximum blood flow velocity of central retinal artery (PSV) and the maximum blood flow velocity of central retinal vein (Vmax) in the non-proliferative group were significantly higher than those in the proliferative group, the difference is statistically significant (P<0.05). In two groups of 244 patients, pearson correlation analysis showed that non-proliferative type 2 diabetic retinopathy was significantly correlated with retinal MRT, CMT thickness, central retinal vascular velocity PSV, Vmax (P<0.05). Multiple linear stepwise regression analysis showed that retinal MRT, CMT thickness, maximum central retinal artery blood flow velocity (PSV) and central retinal vein maximum blood flow velocity (Vmax) were all important factors leading to non-proliferative type 2 diabetic retinopathy (P<0.05). Receiver operating characteristic curve (ROC) curve analysis showed that the area under the curve of retinal thickness combined with central retinal blood flow velocity for non-proliferative type 2 diabetic retinopathy patients was 0.820. Conclusion Patients with non-proliferative type 2 diabetic retinopathy may be accompanied by decreased retinal thickness and increased central retinal blood flow velocity. There is a correlation between retinal thickness and central retinal blood flow velocity and non-proliferative type 2 diabetic retinopathy. The combined diagnosis of non-proliferative type 2 diabetic retinopathy has high value.

Key words: nonproliferative type 2 diabetic retinopathy, retinal thickness, central retinal blood flow velocity, correlation, diagnostic value