Research Progress on Anti-Fatigue Effect of Chinese Medicine

Abstract

Abstract: Fatigue caused by the fast pace of modern social development and competitive pressure has become an important factor affecting people's quality of life. Fatigue not only affects people's life and work, but also endangers people's physical and mental health. Long-term fatigue can induce a variety of diseases if it is not relieved in time. Traditional Chinese medicine has a reliable clinical effect in anti-fatigue and alleviating secondary diseases. In this paper, the understanding of fatigue and the complex mechanism of anti-fatigue of traditional Chinese medicine are reviewed. The application of some representative single Chinese medicine and compound Chinese medicine in anti-fatigue is summarized, and its mechanism of action in anti-fatigue is analyzed. In order to provide reference for further study of traditional Chinese medicine anti-fatigue.

Key words: anti-fatigue by Chinese medicine, mechanism, research on present situation

CLC Number:

R259

TANG Shan-shan. Research Progress on Anti-Fatigue Effect of Chinese Medicine[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(11): 9-12.

References

[1] 唐伟敏,金露,谢亮华,等.芜菁多糖的分离纯化、化学结构及其抗疲劳动物试验研究[J].中国食品学报,2018,18(12):22-31.
[2] MEO S D,NAPOLITANO G,VENDITTI P.Mediators of physical activity protection against ROS-linked skeletal muscle damage[J].Int J Mol Sci,2019,20(12):3024.
[3] KORTE S M,STRAUB R H.Fatigue in inflammatory rheumatic disorders: pathophysiological mechanisms[J].Rheumatology,2019,58(5):35-50.
[4] YUAN X,XU S J,HUANG H Y,et al.Influence of excessive exercise on immunity, metabolism, and gut microbial diversity in an overtraining mice model[J].Scand J Med Sci Sports,2018,28(5):1541-1551.
[5] KAVANAGH J J,MCFARLAND A J,TAYLOR J L.Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions[J].J Physiol,2019,597(1):319-332.
[6] MCGING J J,RADFORD S J,FRANCIS S T,et al.Review article: The aetiology of fatigue in inflammatory bowel disease and potential therapeutic management strategies[J].Aliment Pharmacol Ther,2021,54(4):368-387.
[7] 尹艳,王奕丹,左冬冬,等.中西医治疗慢性疲劳综合征研究进展[J].中医药信息,2019,36(4):122-125.
[8] 李江伟,姚小磊,陈立浩,等.从“肝者,罢极之本”论治视疲劳[J].中医杂志,2024,65(6):649-651,656.
[9] 张晓,曹小勇.从“肝”论治飞行疲劳[J].中国当代医药,2024,31(8):92-96.
[10] 徐放,史哲.景天加灵片治疗脾气虚弱型慢性疲劳综合征的临床观察[J].辽宁中医杂志,2005,48(10):1048-1049.
[11] 潘泗红,张振贤.四君子汤治疗脾虚型慢性疲劳综合征临床研究[J].新中医,2024,56(6):23-28.
[12] 王祥山,朱映黎,吕美豫,等.鹿鞭对肾阴虚及肾阳虚小鼠抗疲劳作用及PI3K-Akt通路机制研究[J].中国中药杂志,2023,48(11):3032-3038.
[13] 杨德龙. 左归丸治疗肾虚型慢性疲劳综合症的临床疗效[J].人人健康,2019,38(22):94-95.
[14] 赖秋媛,谢辑文,陈道睿,等.中医药治疗运动性疲劳研究[J].新中医,2018,50(9):28-33.
[15] 唐宏亮,王雄将,卢栋明,等.推拿干预慢性疲劳综合征研究的系统评价[J].中华中医药学刊,2018,36(6):1363-1368.
[16] ZHANG X,WANG M,ZHOU S.Advances in clinical research on traditional Chinese medicine treatment of chronic fatigue syndrome[J].Evid Based Complement Alternat Med,2020,2020:4715679.
[17] LUO C,XU X,WEI X,et al.Natural medicines for the treatment of fatigue: Bioactive components,pharmacology,and mechanisms[J].Pharmacol Res,2019,148:104409.
[18] ZHU G,ZHANG B,JIANG F,et al.ShenQi FuZheng Injection ameliorates fatigue-like behavior in mouse models of cancer-related fatigue[J].Biomed Pharmacother,2019,111:1376-1382.
[19] GERBER L H,WEINSTEIN A A,MEHTA R,et al.Importance of fatigue and its measurement in chronic liver disease[J].World J Gastroenterol,2019,25(28):3669-3683.
[20] XIE Q,SUN Y,CAO L,et al.Antifatigue and antihypoxia activities of oligosaccharides and polysaccharides from Codonopsis pilosula in mice[J].Food Funct,2020,11(7):6352-6362.
[21] CHI A,SHEN Z,ZHU W,et al.Characterization of a proteinbound polysaccharide from Herba Epimedii and its metabolic mechanism in chronic fatigue syndrome[J].J Ethnopharmacol,2017,203:241-251.
[22] KAVANAGH J J,MCFARLAND A J,TAYLOR J L.Enhanced availability of serotonin increases activation of unfatigued muscle but exacerbates central fatigue during prolonged sustained contractions[J].J Physiol,2019,597(1):319-332.
[23] 要建超. 人参皂苷对小鼠抗疲劳的作用研究[J].中国临床研究,2016,8(29):9-10.
[24] 潘华山,赵奕,冯毅翀.人参总皂甙和人参皂甙 Rg1 对运动性疲劳大鼠中枢神经递质的影响[J].吉林体育学院学报,2009,25(3):57-59.
[25] 安琪,郭梅,申亚君,等.西洋参蒸制前后人参皂苷类成分变化及活性比较研究[J].中国中药杂志,2020,45(18):4404-4410.
[26] JIN T Y,RONG P Q,LIANG H Y,et al.Clinical and Preclinical Systematic Review of Panax ginseng C.A.Mey and Its Compounds for Fatigue[J].Front Pharmacol,2020,11:1031.
[27] 张子腾,马秀娟,刘延刚,等.基于NLRP3 炎症小体的马齿苋水提物抗疲劳作用机制研究[C].武汉:中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛论文集,2015:103-104.
[28] 朴日龙,吴红梅,张红英.马齿苋不同提取物对D-半乳糖致衰老小鼠的抗疲劳作用[J].中国实验方剂学杂志,2013,19(14):240-243.
[29] 韩婷婷,彭垠婷.补气活血类中药抗运动疲劳研究进展[J].体育科技文献通报,2017,25(12):68-70.
[30] 崔笑梅,曹建民,周海涛.巴戟天对大鼠抗运动性疲劳能力及脑组织自由基的影响[J].卫生职业教育,2014,32(19):100-102.
[31] 龙碧波,徐海衡,张新定.巴戟天抗疲劳药理活性的实验研究[J].时珍国医国药,2013,24(2):298-300.
[32] OSMAN W N W,MOHAMED S.Standardized Morinda citrifolia L. And Morinda elliptica L.Leaf extracts alleviated fatigue by improving gly- cogen storage and lipid / carbohydrate metabolism[J].Phytother Res,2018,32(10):2078-2085.
[33] 颜婕,周思敏,田怀军,等.黄芪对缺氧小鼠抗运动疲劳作用的效果研究[J].现代生物医学进展,2013,15(7):2809-2812.
[34] 李成福,李香兰,许青松,等.黄芪水提取液抗运动性疲劳作用的部分机制[J].中国现代医学杂志,2012,22(23):58-61.
[35] 张瑞. 黄芪商品规格等级标准研究与修订及其抗疲劳作用评价[D].太原:山西大学,2019.
[36] 陈丹,朱薇,周兴芹.北五味子水煎液对小鼠抗运动性疲劳的作用机制研究[J].西部中医药,2023,36(7):13-16.
[37] CHI A,ZHANG Y,KANG Y,et al.Metabolic mechanism of a polysaccharide from Schisandra chinensis to relieve chronic fatigue syndrome[J].Int J Biol Macromol,2016,93(Pt.A):322-332.
[38] ZHANG X,JING S,LIN H,et al.Anti-fatigue effect of anwulignan via the NRF2 and PGC-1α signaling pathway in mice[J].Food Funct,2019,10(12):7755-7766.
[39] 司秋霞.淫羊藿对缓解小鼠体力疲劳的实验研究[J].临床医药文献电子杂志,2020,7(23):160,163.
[40] 罗则华,杜倩,奚鑫,等.基于网络药理学的淫羊藿抗疲劳作用机制研究[J].中草药,2020,51(11):2997-3004.
[41] 郭美彤,赵佳奇,韩诚,等.石菖蒲药效物质基础和作用机制研究进展[J].中药药理与临床,2019,35(2):179-184.
[42] ZHU M,ZHU H,TAN N,et al.The effects of Acorus tatarinowii Schott on 5-HT concentrations,TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats[J].J Ethnopharmacol,2014,158(Pt A):431-436.
[43] 孙文丽,MOHAMAD H S,程奇.枸杞化学成分及药用价值国外研究现状[J].中医药信息,2020,37(3):116-120.
[44] 张雅莉,黄晓旭,蔡美琴.枸杞多糖缓解小鼠体力疲劳作用研究及机制探讨[J].营养学报,2015,37(6):616-618.
[45] 周晶,刘宏鹏,周旭,等.枸杞多糖对力竭游泳运动小鼠免疫功能的影响[J].辽宁中医药大学学报,2009,11(8):234-236.
[46] 刘英伟,刘忠民,王浩天,等.枸杞多糖和1,6-二磷酸果糖协同抗运动疲劳作用及其机制[J].吉林大学学报:医学版,2013,38(4):692-696.
[47] 裘淼,熊中奎,吕梦宇.大枣多糖的药理作用研究进展[J].中国现代医生,2018,56(22):161-164.
[48] 王超,王一民,郭飞,等.大枣多糖对 CFS 大鼠的免疫调节作用[J].西北大学学报:自然科学版,2015,45(1):73-78.
[49] 李荣静. 复方中药在抗运动性疲劳的应用研究[J].体育科技文献通报,2021,29(12):205-208.
[50] 臧力铭. 补中益气汤的主要药理作用及研究进展[J].浙江畜牧兽医,2014,39(3):18-19.
[51] 郝红梅,田文婧.补中益气汤对运动性疲劳大鼠血清SOD、MDA、GSH-XP含量的影响[J].山西中医学院学报,2014,15(3):27-28,68.
[52] 潘华山,钟国林,邱文梅,等.补中益气汤对运动性疲劳大鼠胃肠功能的影响[J].广州中医药大学学报,2013,30(6):864-867.
[53] 陈跃琳,何瑾亮,陈文渊,等.六味地黄丸( 汤) 的研究及临床应用[J].中医临床研究,2011,3(12):41-42.
[54] 陈松海,刘秋琼,麦颖娟,等.六味地黄汤对运动性疲劳小鼠的作用及血清乳酸、睾酮的影响[J].中药材,2011,34(11):1769-1770.
[55] 李艳清. 柴胡疏肝散加减治疗慢性疲劳综合征的临床效果分析[J].中国医药指南,2012,10(32):269-270.
[56] 张彩,徐划萍.柴胡疏肝散抗小鼠运动性疲劳的拆方研究[J].中华中医药学刊,2011,29(9):2049-2051.