Abstract: Objective To analyze the modeling elements of experimental animal models of vascular dementia, and to provide reference for the establishment of stable and reliable animal models of vascular dementia experimental research. Methods With "vascular dementia + animal model" as the theme, the experimental studies on vascular dementia were searched from major databases from January 1, 2011 to October 1, 2021, respectively. Statistical analysis was carried out on related modeling methods and index detection in literature. Results A total of 148 valid literatures were screened. Male Wistar rats and male SD rats were mostly selected for VD model animals, and their body weight ranged from 200g to 300g. Permanent ligation of bilateral common carotid arteries was usually used for modeling. Morris water maze was used to detect animal behavior changes, oxidative stress and cholinergic nerve indexes, and pathological state of brain and hippocampal tissues, which reflected the pathophysiological state of VD animal models. Conclusion In the future, we should focus on optimizing the modeling method to improve the success rate of modeling and reduce the mortality rate.To establish the animal model of vascular dementia with Chinese and western medicine.

Key words: vascular dementia, data mining, animal model