Abstract: Objective To explore the pharmacological effects of Suanzaoren decoction with differential diagnosis and modification in the treatment of hypertension combined with sleep disorders. Methods From January 2022 to December 2023, 98 hypertensive patients with sleep disorders were selected from Tai'an Traditional Chinese Medicine Hospital. They were randomly divided into two groups of 49 each using a random number table. The control group received conventional Western medicine treatment during treatment, while the study group used a traditional Chinese medicine decoction called Suanzaoren decoction on the basis of Western medicine treatment, with adjustments made according to the syndrome. Compare the total effective rate and incidence of adverse reactions between the two groups, and compare blood pressure indicators, sleep indicators, psychological scores, quality of life scores, and liver and kidney function indicators before and after treatment in both groups. Results Regarding the total effective rate, the values in the study group were higher than those in the control group (P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the study group and the control group (P>0.05). After treatment, systolic and diastolic blood pressure were measured, and both blood pressure were lower than before treatment, while the study group was lower than the control group（P<0.05）. After treatment, various sleep data monitored at night in both groups improved compared to before treatment, and in the inter group comparison, the sleep latency of the study group was shorter than that of the control group, the actual sleep duration of the study group was longer than that of the control group, and the sleep quality score of the study group was lower than that of the control group, （P<0.05）. After treatment, the anxiety score and depression score of both groups of patients decreased compared to before treatment, while the two psychological scores of the study group were lower than those of the control group（P<0.05）. After treatment, quality of life in both groups, on four dimensions, was higher in both groups than in the same group before treatmentThe study group was higher than the control group (P<0.05). Regarding liver and kidney function indicators, there was no statistically significant difference between the two groups before and after treatment (P>0.05), and there was no statistically significant difference between the groups (P>0.05). Conclusion When treating patients with hypertension and sleep disorders, the use of Suanzaoren Tang has significant therapeutic effects. It can not only control blood pressure levels, but also improve patients' sleep conditions, alleviate sleep disorders, and help improve their psychological and quality of life. Moreover, the combination of Western medicine and Suanzaoren Tang does not increase the risk of adverse reactions and has good safety.

Key words: hypertension, sleep disorders, Sour jujube seed soup, Traditional Chinese Medicine