The Clinical Application Progress of Rehmannia Decoction in Cerebrovascular Diseases

Abstract

Abstract: As a classic traditional Chinese medicine formula, Dihuang Yinzi has the effects of nourishing kidney yin, tonifying kidney yang, and opening the orifices and resolving phlegm. It is of great significance in promoting blood circulation in the brain, protecting neurons, improving patient memory, improving learning ability, and restoring cognitive function. Currently, Dihuang Yinzi is widely used in the clinical treatment of cerebrovascular diseases and has shown unique advantages. This article aims to review the clinical application and mechanism of action of Dihuang Yinzi in cerebrovascular diseases, especially Parkinson's disease (PD), Alzheimer's disease (AD), vascular dementia (VD) and other diseases, and explore the effective ingredients and pharmacological effects of Dihuang Yinzi, providing more scientific and reasonable treatment strategies for clinical practice.

Key words: Dihuang Yinzi, cerebrovascular disease, parkinson's disease, alzheimer's disease, vascular dementia

CLC Number:

R287

ZHAO Yan-yun, SUN Ying-ying, YANG Zhou, LIU Xiao-li, ZHOU Jian-guo. The Clinical Application Progress of Rehmannia Decoction in Cerebrovascular Diseases[J]. ZHONGHUA YANGSHENG BAOJIAN, 2025, 43(1): 76-78.

References

[1] 张心邈,徐曼,丁玲玲,等.脑血管病临床决策支持系统对卒中医疗服务质量关键绩效指标的影响研究[J].中国卒中杂志,2024,19(1):120-124.
[2] 刘影哲,吕蓉,杨建飞,等.地黄饮子治疗血管性痴呆的网络药理学分子机制研究[J].现代中西医结合杂志,2022,31(21):2989-2996.
[3] 徐晶,姚鹏宇,赵家有,叶天士运用地黄饮子经验探析[J].浙江中医杂志,2021,56(4):235-237.
[4] 张秀芬,王思梦,白建英,等.经典名方地黄饮子的古代文献考究[J].中国实验方剂学杂志,2020,26(14):59-64.
[5] 窦金金,罗泓楠,李红颖,等.地黄饮子防治老年痴呆疾病研究进展[J].现代中药研究与实践,2023,37(1):92-98.
[6] 陈治,马振宇,叶郁葱.地黄饮子联合针刺加麦粒灸对恢复期脑梗死患者神经功能重建和脑血流动力学的影响[J].浙江中医杂志,2022,57(6):416-417.
[7] 聂丽媛,白帅东,张世霞,等.地黄饮子的现代研究进展[J].山西中医药大学学报,2022,23(1):60-64.
[8] BLESA J, FOFFANI G, DEHAY B, et al.Motor and non-motor circuit disturbances in early Parkinson disease:which happens first?[J].Nat Rev Neurosci,2022,23(2):115-128.
[9] QI S, YIN P, WANG L, et al.Prevalence of Parkinson's Disease:A Community-Based Study in China[J].Movement Disorders,2021,36(12):2940-2944.
[10] 张世霞,李聚林,李东明,等.地黄饮子对帕金森病肾虚证大鼠运动行为的影响[J].中国药物与临床,2023,23(5):273-277.
[11] 朱斌,王策,徐青青.地黄饮子联合认知康复治疗帕金森病轻度认知障碍临床研究[J].新中医,2021,53(17):38-41.
[12] 张秀琳,惠振,王苏雷,等.加减地黄饮子治疗帕金森病疼痛临床研究[J].陕西中医,2021,42(5):620-624.
[13] 惠振,张臻年,张秀琳,等.加减地黄饮子对老年帕金森病便秘的疗效观察[J].老年医学与保健,2021,27(2):317-320.
[14] 薛静,赵迪,王丽晔,等.地黄饮子对多系统萎缩、阿尔茨海默病及帕金森病异病同治机制初探[J].现代中西医结合杂志,2022,31(11):1577-1582.
[15] 田金洲,解恒革,王鲁宁,等.中国阿尔茨海默病痴呆诊疗指南(2020年版)[J].中华老年医学杂志,2021,40(3):269-283.
[16] GUO T, ZHANG D, ZENG Y, et al.Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease[J].Mol Neurodegener,2020,15(1):40.
[17] 张莹林,姚俊岩.神经炎症在阿尔茨海默病中作用的研究进展[J].国际麻醉学与复苏杂志,2022,43(1):90-94.
[18] 宋志勇,穆亚敏.地黄饮子对阿尔茨海默病模型小鼠海马组织氧化应激及炎性因子表达的影响[J].吉林医学,2022,43(10):2597-2600.
[19] 李少创,韩诚,张正,等.地黄饮子调节海马神经突触可塑性作用机制研究[J].山东中医药大学学报,2024,48(3):337-347.
[20] 帅月圆,韩诚,曹建华,等.基于1H-NMR血清代谢组学的阿尔茨海默病肾虚精亏证生物学机制及地黄饮子的干预作用研究[J].山西中医药大学学报,2021,22(4):252-257,263.
[21] 王璐,白雨朦,李晓宇,等.肉苁蓉总苷对阿尔茨海默病模型大鼠学习认知功能和氧化应激的影响[J].解剖学杂志,2020,43(3):194-199,275.
[22] 靳蕊,徐家淳,王凯,等.基于网络药理学的地黄饮子治疗阿尔茨海默病的机制[J].中国老年学杂志,2023,43(12):2913-2920.
[23] 窦金金,罗泓楠,李红颖.地黄饮子防治老年痴呆疾病研究进展[J].现代中药研究与实践,2023,37(1):92-98.
[24] 陈昭,吴林,蓝雪琳,等.血管性痴呆发病机制中西医研究进展[J].辽宁中医药大学学报,2022,24(1):40-44.
[25] 宋明容,任佳慧,陈军磊,等.地黄饮子治疗痴呆效果研究的Meta分析[J].阿尔茨海默病及相关病杂志,2024,7(2):114-121.
[26] 张正,李少创,秦亚莉,等.基于医案数据挖掘探讨地黄饮子临床应用规律[J].辽宁中医药大学学报,2023,25(12):121-126.
[27] 严淑婷,李若岚,白杨,等.地黄饮子加减治疗血管性痴呆研究进展[J].现代中医药,2020,40(6):97-101.
[28] 袁雨町,贾建新,杨志甫.肉苁蓉总苷对脑缺血再灌注大鼠氧化应激损伤及细胞凋亡的影响[J].包头医学院学报,2023,39(12):8-12.
[29] 孙龙,王革生,吴彦青.地黄饮子联合穴位针刺对急性脑梗死患者神经功能及脑氧代谢的影响[J].中国中医急症,2023,32(8):1443-1446.
[30] 朱化珍,张雪丹,刘志浩,等.地黄饮子加减辅助治疗中风后吞咽障碍研究概况[J].中国民族民间医药,2022,31(22):46-49.
[31] 许彦来,孙晓芳,许晓雯.地黄饮子加减与补阳还五汤治疗中风后失语症的临床观察[J].西部中医药,2023,36(10):141-144.
[32] 周雨慧,苗明三,李晓宁,等.地黄饮子加减方对血管性痴呆模型大鼠行为学及神经保护作用的影响[J].中药药理与临床,2020,36(1):46-51.
[33] 胡长春,秦合伟,姬令山.地黄饮子治疗肾虚血瘀型血管性痴呆的临床研究[J].中国疗养医学,2023,32(3):306-309.
[34] 衡先培,杨柳清.中医内科临床诊疗指南·老年衰弱(制定)[J].中华中医药杂志,2020,35(8):4030-4035.
[35] 程雪桦,周雯,何菡,等.地黄饮子治疗肾精亏虚型老年衰弱综合征的临床研究[J] 老年医学与保健,2023,29(6):1302-1307.
[36] 周妍妍,姜璐璐,井宏颖.地黄饮子抗衰老机制的实验研究进展[J].中国老年学杂志,2023,43(4):987-990.
[37] 毛怡君,薛常虎,范惠,等.脑卒中患者吞咽障碍恢复不良影响因素的Meta分析[J].神经疾病与精神卫生,2024,24(3):190-198.
[38] 郑微,胡楠.地黄饮子联合舌项针治疗中风后假性球麻痹吞咽功能障碍临床疗效观察[J].辽宁中医杂志,2023,50(1):151-154.
[39] 时沛,许璐,冯永鹏,等.项针联合地黄饮子治疗脑卒中后吞咽功能障碍患者60例临床观察[J].宁夏医学杂志,2022,44(10):954-956.