Abstract: Objective To observe the effect of Yindan Xinnaotong soft capsule combined with recombinant tissue-type plasminogen activator (rt-PA) intravenous thrombolysis on the overall benefit level of patients with ischemic stroke. Methods Study sample source: 100 ischaemic stroke patients admitted to the Department of Neurology of Xixiang County Hospital of Traditional Chinese Medicine, sample selection time: between January 2022 and December 2023 period. The enrolled patients were divided into two groups using the random number table method, 50 cases in the control group, in which rt-PA intravenous thrombolytic therapy was carried out, and 50 cases in the combined group, in which the patients in the group were combined with Yindan Xinguintong soft capsule therapy on the basis of the control group, to compare the clinical efficacy, the recovery of neurological function [Stroke Scale (NIHSS), Modified Rankin Scale (mRs)], haemato-rheology, blood lipids [triacylglycerol (TG), total body fat (TG), total body fat (TG) and blood lipid [triacylglycerol (TG), and total body fat (TL)]. glycerol (TG), total cholesterol (TC), whole blood viscosity (WBV) and erythrocyte sedimentation rate (ESR)], oxidative stress [serum nitric oxide (NO), malondialdehyde (MDA)]. Results The treatment effect of the combined group was better than that of the control group, and the difference was statistically significant (P<0.05); there was no statistical difference between the scores of NHISS and mRs before treatment in the two groups (P>0.05). After treatment, the scores of NHISS and mRs in the combined group decreased significantly,with statistical difference (P<0.05). There was no statistical difference in the expressions of TC, TG, WBV and ESR between the two groups before treatment (P>0.05). After treatment,the expressions of TC, TG and WBV in the two groups decreased,while the expressions of ESR increased. Moreover,the decreases of TC, TG and WBV in the combined group were larger than those in the control group, and the differences were statistically significant (P<0.05), comparison of MDA and NO between the two groups before treatment, the difference was not statistically significant (P>0.05), after treatment, NO decreased and MDA increased in both groups,and the magnitude of NO decrease and MDA increase in the combined group was greater than that of the control group, and the difference was statistically significant (P<0.05). Conclusion Ischemic stroke patients in rt-PA treatment based on the combination of Yindan Xinhuantong soft capsule, the therapeutic effect is better,the patient's neurological function recovery is more complete, and is conducive to the improvement of the patient's blood lipids, blood rheology and oxidative stress response.

Key words: ischemic stroke, recombinant tissue-type plasminogen activator, Yindan Xinnaotong soft capsule, neurological function