Evaluation Value of Biochemical Indexes of Renal Function in Prognosis of Patients with Acute Pulmonary Embolism

Abstract

Abstract: Objective To investigate the prognostic value of biochemical indexes of renal function in patients with acute pulmonary embolism. Methods The data of 231 patients with acute pulmonary embolism treated in the People's Hospital of Inner Mongolia Autonomous Region from January 2020 to December 2023 were retrospectively analyzed. The outcomes of the patients were divided into good outcomes and poor outcomes. Describe the outcomes of all patients (grouping). Univariate analysis of prognosis in patients with acute pulmonary embolism and multivariate analysis of prognosis in patients with acute pulmonary embolism. Predictive model and efficacy of prognosis in patients with acute pulmonary embolism. Results Of the 231 patients included in the study, 85 (36.80%) were judged to have a poor prognosis and 146 (63.20%) were judged to have a good prognosis. The results of univariate analysis showed that there were statistically significant differences in creatinine clearance, urea nitrogen, uric acid, cystatin C, sodium ion and calcium ion levels among patients with different prognosis (P<0.05). logistic multivariate analysis obtained the model equation as follows: ln (P/1-P) =23.853-0.106×creatinine clearance +0.372×urea nitrogen+0.008×uric acid +2.926×cystatin C-9.909×Ca²⁺. The nomogram risk model was constructed based on the variables screened by multi-factor analysis, and the C-index was 0.792. The average absolute error of calibration curve is 0.022. The ROC curve was used to predict the prognosis of patients with acute pulmonary embolism using independent influencing factors and P-value prediction probability, and the areas under the curve were 0.930, 0.698, 0.714, 0.656, 0.733, 0.966, respectively. Conclusion Creatinine clearance, urea nitrogen, uric acid, cystatin C and calcium levels are closely related to poor short-term prognosis in patients with acute pulmonary embolism. Monitoring renal function biochemical indexes in the diagnosis and treatment of patients with acute pulmonary embolism may help reduce adverse prognostic events.

Key words: kidney function, acute pulmonary embolism, urea nitrogen, uric acid, creatinine clearance

CLC Number:

R563.5

WANG Xiao-yu. Evaluation Value of Biochemical Indexes of Renal Function in Prognosis of Patients with Acute Pulmonary Embolism[J]. ZHONGHUA YANGSHENG BAOJIAN, 2024, 42(21): 43-47.

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