Abstract: Objective To explore the effect of ultrasound-guided high-intensity focused ultrasound (HIFU) on the treatment of uterine fibroids and its impact on residual fibroids and oxidative stress. Methods 84 patients with uterine fibroids, admitted to Yantai Laiyang central hospital from August 2020 to August 2023, were randomly divided into two groups. The control group underwent laparoscopic myomectomy, while the study group received HIFU treatment. Surgical outcomes, complication rates, residual fibroid rates, and oxidative stress markers [malondialdehyde (MDA), advanced oxidative protein products (AOPP), reactive oxygen species (ROS)] were evaluated, and immune function markers [Tlymphocytes (CD3⁺, CD4⁺, CD4⁺/CD8⁺)] were also assessed into two groups. Results Compared with the control group, the study group had shorter surgical time, postoperative exhaust time, hospital stay, and less intraoperative bleeding, with statistically significant differences (P<0.05). Compared with the control group, the incidence of postoperative complications and residual fibroids in the study group were lower, and the difference was statistically significant (P<0.05). There was no statistically significant difference (P>0.05) in MDA, AOPP, and ROS levels between the two groups before surgery. However, compared to before surgery, the MDA, AOPP, and ROS levels in the two groups increased on the first day after surgery, and the difference was statistically significant (P<0.05). However, compared to the control group, the MDA, AOPP, and ROS levels in the study group were lower, and the difference was statistically significant (P<0.05). There was no statistically significant difference (P>0.05) in the comparison of CD3⁺, CD4⁺, and CD4⁺/CD8⁺between the two groups before surgery. Compared with before surgery, the levels of CD3⁺, CD4⁺, and CD4⁺/CD8⁺in the two groups decreased 1 day after surgery. However, compared with the control group, the levels of CD3⁺, CD4⁺, and CD4⁺/CD8⁺in the study group were higher, and the difference was statistically significant (P<0.05). Conclusion :Ultrasound-guided HIFU treatment of uterine fibroids has a low residual rate of fibroids and a low incidence of fibroids, which has little effect on oxidative stress and immune function, and is safe and effective.

Key words: uterine fibroids, ultrasound-guided high-intensity focused ultrasound, residual fibroids, oxidative stress, complications, immunologic function