Abstract: Objective To analyze the application value of urinary medium factor in the diagnosis of bladder cancer. Methods From July 2019 to June 2023, 82 patients with bladder cancer in Xuecheng District People's Hospital and Zaozhuang Municipal Hospital were selected as group A, 82 patients with benign urinary system diseases in the same period of time were selected as group B, and 82 healthy subjects in the same period of time were selected as group C. Urine midterm factor test was performed in all three groups, and the differences in test results among the three groups were compared. The diagnostic value of urinary intermediate factor was evaluated by histopathological examination. Finally, the correlation between the clinical data of patients with bladder cancer and urine metaphase factors was observed, and the correlation analysis between clinical characteristics and urinary intermediate factor levels in patients with bladder cancer was analyzed by univariate analysis. Results Urine metaphase factor in group A was significantly higher than that in groups B and C, the difference was significant (P<0.05), urine metaphase factor in group B was higher than that in group C, the difference was significant (P<0.05). The diagnostic results of urinary mid-stage factor were 82 cases of bladder cancer, 16 cases missed diagnosis, and 6 cases misdiagnosed. The sensitivity of urinary mid-stage factor was 80.5%, the specificity was 90.2%, the accuracy was 87.0%, the positive predictive value was 80.5%, and the negative predictive value was 90.2%. There were significant differences in urinary medium factor levels among different tumor numbers, muscle invasiveness and lymph node metastasis in patients with bladder cancer (P<0.05). Conclusion Urinary medium term factor has high sensitivity and specificity in the diagnosis of bladder cancer, and can be used as an evaluation index for non-invasive diagnosis.

Key words: urine intermediate factor, bladder cancer, non-invasive diagnosis