Abstract: Objective To explore and analyze the efficacy and safety of four hole laparoscopy for colorectal cancer. Methods A total of 86 cases of patients with colorectal cancer who underwent Elective surgery in People's Hospital of Dali Bai Autonomous Prefecture from January 2020 to January 2023 were selected as the study subjects. Accorded to random number table, 86 patients were divided into the four hole group (43 cases) and the traditional group (43 cases). The traditional group were treated with traditional open surgery, and the four hole group were treated with four hole Laparoscopy. The effectiveness and safety of the two groups were recorded. Results The surgical time, intraoperative bleeding, postoperative first exhaust time, postoperative first defecation time, postoperative first meal time, and postoperative hospitalization time of the four hole group were significantly shorter than those of the traditional group (P<0.05). The visual analog pain scale (VAS) scores of the four hole group on postoperative day 1, 7, and 14 were lower than those of the traditional group, and the difference was statistically significant (P<0.05). The incidence of intestinal obstruction, incision infection, anastomotic leakage, urinary retention, pulmonary infection and other complications 14 days after operation in the four hole group was lower than that in the traditional group, with a statistically significant difference (P<0.05). The serum levels of superoxide dismutase and malondialdehyde in the two groups were higher on the 14th day after surgery than on the 1st day before surgery, and lower on the 1st day before surgery. The serum levels of superoxide dismutase and malondialdehyde in the four well group were statistically significant compared to the traditional group on the 14th day after surgery (P<0.05). The general health status, mental health, physical pain, vitality index, emotional function, and other quality of life scores of the four hole group were higher than those of the traditional group 14 days after surgery, and the difference was statistically significant (P<0.05). Conclusion Four hole laparoscopy for colorectal cancer has good safety and effectiveness, which can alleviate patients' pain, promote patients' rehabilitation, reduce the incidence of complications, improve oxidative stress response, and improve patients' quality of life.

Key words: four hole method, laparoscopy, colorectal cancer, safety, effectiveness, superoxide dismutase, quality of Life