Abstract: Objective To observe the curative effect of thrombin combined with proton pump inhibitor on upper gastrointestinal bleeding. Methods A total of 320 patients with upper gastrointestinal bleeding admitted to our hospital from January 2020 to January 2023 were randomly divided into control group and observation group, with 160 patients in each group. The control group was treated with proton pump inhibitor (omeprazole injection), while the observation group was treated with thrombin on the basis of this. Hemostasis (hemostasis time, blood transfusion, rebleeding rate, hospitalization time), Glasgow-Blatchford bleeding score (GBS), treatment efficiency and adverse reactions were compared between the two groups. Results The hemostatic time, blood transfusion volume, rebleeding rate and hospitalization time in the observation group were lower than those in the control group, with statistical significance (P<0.05).Before treatment, there was no significant difference in GBS scores between the two groups (P>0.05). After treatment, the GBS scores of the two groups decreased, and the scores of the observation group were lower than those of the control group, with significant difference (P<0.05).The effective rate in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05).There was no significant difference in the adverse reaction rate between the observation group and the control group (P>0.05). Conclusion Thrombin combined with proton pump inhibitor is effective in the treatment of upper gastrointestinal bleeding, which can improve the hemostasis efficiency and relieve the critical degree of bleeding, and will not increase the adverse reactions, so it has the significance of popularization and use.

Key words: thrombin, proton pump inhibitor, upper gastrointestinal bleeding, hemostasis, GBS