Abstract: Objective To investigate the effect of Lugua polypeptide injection on bone mineral density in patients with thoracolumbar fractures. Methods 80 patients with thoracolumbar fractures who were treated at the Fifth People's Hospital of Wujiang District, Suzhou City from May 2021 to June 2023 were selected. All patients were treated conservatively and fixed with external fixators. They were randomly divided into an observation group (conventional Western medicine treatment+deer melon peptide injection, n=40) and a control group (conventional Western medicine treatment, n=40) using a random number table method. The bone mineral density, bone metabolism index, JOA and VAS scores , the bed rest time ,and the occurrence of adverse reactions were compared between the two groups. Results After treatment, the bone mineral density of the lumbar vertebrae and the right femoral neck in the two groups were significantly higher than before treatment (P<0.05), and the bone mineral density of the lumbar vertebrae and the right femoral neck in the observation group was higher than that in the control group (P<0.05). After treatment, the levels of parathyroid hormone, osteocalcin and calcitonin in the two groups were improved in different degrees (P<0.05), and the levels of parathyroid hormone in the observation group were significantly higher than those in the control group (P<0.05), while the levels of osteocalcin and calcitonin were significantly lower than those in the control group (P<0.05). After treatment, the JOA and VAS scores of the two groups were not improved to any extent (P<0.05), and the JOA score of the observation group was significantly higher than that of the control group (P<0.05), and the VAS score was significantly lower than that of the control group (P<0.05). The bed rest time in the observation group was significantly shorter than that in the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion Lugua polypeptide injection can increase the bone density of patients with thoracolumbar fractures, regulate bone metabolism, promote the recovery of lumbar function and relieve pain, and it is safe and worthy of clinical promotion.

Key words: thoracolumbar fracture, Cervus and Cucumis polypeptide injection, bone density