ZHONGHUA YANGSHENG BAOJIAN ›› 2024, Vol. 42 ›› Issue (16): 25-27.

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Study on the Therapeutic Effect of Modified Wuhu Decoction Combined with Budesonide Suspension in Paediatric Cough Variant Asthma

ZHANG Mu-er1, ZHU Su-juan2, LIN Rui-shuang3, GUO Dai-nian2,*   

  1. 1. Pharmacy of TCM, Shantou Hospital of TCM, Shantou GuangDong 515041, China;
    2. Drug Clinical Trial Institute, Cancer Hospital Affiliated to Shantou University Medical College, Shantou GuangDong 515041, China;
    3. Department of Traditional Chinese Medicine, Cancer Hospital Affiliated to Shantou University Medical College, Shantou GuangDong 515041, China
  • Online:2024-08-16 Published:2024-08-13

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Abstract: Objective To investigate the effect ofmodified Wuhu decoction combined with Budesonide suspension on cough variant asthma in children. Methods Selected 96 cases of patients with cough variant asthma admitted to Shantou Hospital of Traditional Chinese Medicine from January 2020 to December 2022, divided into two groups by taking the randomized numerical table method. The control group was treated with Budesonide suspension, and the observation group was treated with modified Wuhu Decoction.The symptoms of the two groups were evaluated, and the forced expiratory volume to forced Vital capacity ratio (FEV1/FVC), maximum ventilation volume scale (MVV), maximum middle expiratory flow (MMF) and peak expiratory flow (PEF) were measured, and the levels of serum interleukin-5 (IL-5), matrix metalloproteinase-9 (MMP-9), Eosinophil cationic protein (ECP) and IL-8 were measured. Results After treatment, the scores of cough, nasal discharge, throat itching, shortness of breath, sneezing and nasal congestion in both groups were significantly decreased (P<0.05), and the observation group was significantly lower than the control group (P<0.05). After treatment, FEV1/FVC, MVV, MMF and PEF in both groups were significantly improved (P<0.05), and the observation group was significantly better than the control group (P<0.05). After treatment, the serum levels of IL-5, MMP-9, ECP and IL-8 in both groups were significantly decreased (P<0.05), and the observation group was significantly lower than the control group (P<0.05). Conclusion Jiawei Wuhu Decoction combined with Budesonide suspension has a significant effect on cough variant asthma in children, which can significantly improve lung function and relieve symptoms. Its mechanism may be related to the reduction of serum IL-5, MMP-9, ECP and IL-8 levels, which is worth promoting.

Key words: Flavored Five Tiger Soup, budesonide suspension, cough variant asthma

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