Abstract: Objective To investigate the therapeutic effect of Xuansu Zhike Decoction combined with inhaled glucocorticoid in the treatment of bronchial pneumonia in children and the influence of serum vascular intercellular adhesion molecule 1 (VCAM-1) and Th1/Th2 cytokines. Methods From May 2021 to May 2023,80 children of bronchopneumonia were selected. The random number table method was divided into two groups, 40 cases each. The control group was treated with glucocorticoids, and the test group was treated with glucocorticoids combined with Xuanwu cough soup. The time to disappearance of clinical symptoms was recorded in both groups of children, the clinical efficacy was evaluated, and the serum intercellular adhesion molecule-1 (VCAM-1), interferon (IFN) - γ, and interleukin (IL-4) levels were detected before and after treatment. Results Compared with the control group, The duration of cough, wheezing and shortness of breath decreased significantly (P<0.05), However, the fever disappearance time of the two groups was not significant difference(P>0.05); The overall response rate of the patients in the test group was 95.00%, The overall response rate of the control patients was 77.50%, The total response rate of patients in the test group was significantly higher than that in the control group (P<0.05); Compared with the control group, the serum IFN- γ, IL-4 and IFN- γ / IL-4 ratios improved significantly better than those of the control group (P<0.05), and the serum VCAM-1 was not significant difference(P>0.05); no significant adverse effects were seen in either group. Conclusion Xuansu cough relieving decoction combined with glucocorticoid in the treatment of pediatric bronchopneumonia can effectively promote the improvement of symptoms, improve clinical efficacy, and regulate the imbalance of Th1/Th2 cells.

Key words: bronchopneumonia, Xuansu cough soup, glucocorticoid, vascular intercellular adhesion molecule-1, Th1/Th2 cells