Abstract: Objective To explore the effect of Huayu Qingsan Decoction in combination with internal and external therapy on non proliferative type 2 Diabetic retinopathy. Methods A total of 80 patients with nonproliferative type 2 Diabetic retinopathy admitted to our hospital from January 2023 to July 2023 were selected as the study subjects. All patients were divided into an observation group and a control group by lot drawing, with 40 cases in each group. The control group was treated with simple basic Sex therapy, and the observation group was treated with Huayu Qingsan Decoction combined with internal and external treatment on the basis of the control group. The changes of TCM syndrome integral, fundus examination related indicators and central retinal artery blood flow parameters before and after treatment were compared between the two groups. Results There was no significant differencein the scores of traditional Chinese medicine syndromes related to visual acuity, thirst, irritability, sleep, appetite, defecation, urination, tongue condition, and pulse condition between the two groups of patients before treatment (P>0.05) . After treatment, the scores of traditional Chinese medicine syndromes related to visual acuity, thirst, irritability, sleep, appetite, defecation, urination, tongue condition, and pulse condition decreased in both groups of patients, with the observation group being lower than the control group (P<0.05). There was no significant difference in retinal CNP area, retinal MCT, retinal VT area, number of microvascular tumors, and CMT between the two groups before treatment (P>0.05). After treatment, the retinal CNP area, retinal MCT, retinal VT area, number of microvascular tumors, and CMT of the two groups of patients decreased, and the observation group was lower than the control group (P<0.05). There was no significant difference in the blood flow parameters of the central retinal artery between the two groups of patients before treatment (P>0.05). After treatment, the RI of the two groups of patients decreased, and the observation group was lower than the control group, while the EDV and PSV increased. The observation group was higher than the control group (P<0.05). Conclusion Huayu Qingsan Decoction is effective in the treatment of non proliferative type 2 Diabetic retinopathy, which can improve the clinical symptoms, the degree of fundus disease and retinal hemodynamics.

Key words: Huayu Qingsan Decoction, internal and external combination therapy, non proliferative type 2 diabetic retinopathy, clinical efficacy