Abstract: Objective To investigate the correlation between iron saturation, transferrin and peptic ulcer complicated with malnutrition. Methods A total of 80 patients with peptic ulcer complicated with malnutrition in our hospital from August 2020 to July 2023 were selected as the research object and divided into the observation group, and 80 patients with peptic ulcer without malnutrition in our hospital in the same period were selected as the control group. The general clinical data, iron saturation and transferrin expression levels of the two groups were compared, Logistic regression analysis was used to analyze the independent influencing factors of peptic ulcer complicated with malnutrition. Subsequently, 80 patients with peptic ulcer complicated with malnutrition were divided into three subgroups according to body mass index (BMI), namely, BMI<16 kg/m² was severe malnutrition group (n=12), BMI 16~16.9 BMI<16 kg/m² was moderate malnutrition group (n=28), BMI 17~18.4 kg/m² was mild malnutrition group (n=40). The iron saturation and transferrin expression levels of the three groups were compared, and Spearman correlation analysis method was used to analyze the iron saturation, transferrin expression level, and the iron saturation, transferrin expression level of the three groups The correlation between transferrin and the severity of peptic ulcer complicated with malnutrition. Results There were no significant differences in gender, duration of peptic ulcer, HP test results and alcohol consumption between the observation group and the control group (P>0.05). There were significant differences in age, maximum ulcer diameter, BMI, ulcer location, iron saturation and transferrin levels between the two groups (P<0.05); Logistic regression analysis showed that age, BMI, increased iron saturation and decreased transferrin were independent risk factors for peptic ulcer complicated with malnutrition (P<0.05); There were significant differences in iron saturation and transferrin expression among the three groups, and iron saturation in severe malnutrition group was higher than that in moderate malnutrition group and mild malnutrition group, while transferrin was lower than that in moderate malnutrition group and mild malnutrition group (P<0.05). Spearman correlation analysis showed that iron saturation was positively correlated with the severity of peptic ulcer complicated with malnutrition (P<0.05). Transferrin was negatively correlated with the severity of peptic ulcer complicated with malnutrition (P<0.05). Conclusion The increase of iron saturation and the decrease of transferrin are the independent influencing factors of peptic ulcer complicated with malnutrition, and have obvious correlation with the severity of malnutrition. Therefore, the clinical patients with peptic ulcer with increased iron saturation and decreased transferrin should be alert to the occurrence of malnutrition and take nutritional supplement measures in time.

Key words: iron saturation, transferrin, peptic ulcer, malnutrition, relativity